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Title	Goodman & Gilman's the pharmacological basis of therapeutics
Publish Info	New York : McGraw-Hill, ©2001
Edition	10th ed. / editors, Joel G. Hardman, Lee E. Limbird ; consulting editor, Alfred Goodman Gilman

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Contents

Sect. I General Principles 1

Introduction / Alfred Goodman Gilman 1

1 Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination / Grant R. Wilkinson 3

2 Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect / Elliott M. Ross, Terry P. Kenakin 31

3 Principles of Therapeutics / Alan S. Nies 45

4 Principles of Toxicology and Treatment of Poisoning / Curtis D. Klaassen 67

5 Gene Therapy / Christopher S. Rogers, Bruce A. Sullenger, Alfred L. George, Jr. 81

Sect. II Drugs Acting at Synaptic and Neuroeffector Junctional Sites 113

6 Neurotransmission: The Autonomic and Somatic Motor Nervous Systems / Brian B. Hoffman, Palmer Taylor 115

7 Muscarinic Receptor Agonists and Antagonists / Joan Heller Brown, Palmer Taylor 155

8 Anticholinesterase Agents / Palmer Taylor 175

9 Agents Acting at the Neuromuscular Junction and Autonomic Ganglia / Palmer Taylor 193

10 Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists / Brian B. Hoffman 215

11 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists / Elaine Sanders-Bush, Steven E. Mayer 269

Sect. III Drugs Acting on the Central Nervous System 291

12 Neurotransmission and the Central Nervous System / Floyd E. Bloom 293

13 History and Principles of Anesthesiology / Charles Beattie 321

14 General Anesthetics / Alex S. Evers, C. Michael Crowder 337

15 Local Anesthetics / William A. Catterall, Kenneth Mackie 367

16 Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium / Eric J. Moody, Brett A. Simon, Roger A. Johns 385

17 Hypnotics and Sedatives / Dennis S. Charney, S. John Mihic, R. Adron Harris 399

18 Ethanol / Michael F. Fleming, S. John Mihic, R. Adron Harris 429

19 Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders / Ross J. Baldessarini 447

20 Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania / Ross J. Baldessarini, Frank I. Tarazi 485

21 Drugs Effective in the Therapy of the Epilepsies / James O. McNamara 521

22 Treatment of Central Nervous System Degenerative Disorders / David G. Standaert, Anne B. Young 549

23 Opioid Analgesics / Howard B. Gutstein, Huda Akil 569

24 Drug Addiction and Drug Abuse / Charles P. O'Brien 621

Sect. IV Autacoids; Drug Therapy of Inflammation 643

Introduction / Jason D. Morrow, L. Jackson Roberts II 643

25 Histamine, Bradykinin, and their Antagonists / Nancy J. Brown, L. Jackson Roberts II 645

26 Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor / Jason D. Morrow, L. Jackson Roberts II 669

27 Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout / L. Jackson Roberts II, Jason D. Morrow 687

28 Drugs Used in the Treatment of Asthma / Bradley J. Undem, Lawrence M. Lichtenstein 733

Sect. V Drugs Affecting Renal and Cardiovascular Function 755

29 Diuretics / Edwin K. Jackson 757

30 Vasopressin and Other Agents Affecting the Renal Conservation of Water / Edwin K. Jackson 789

31 Renin and Angiotensin / Edwin K. Jackson 809

32 Drugs Used for the Treatment of Myocardial Ischemia / David M. Kerins, Rose Marie Robertson, David Robertson 843

33 Antihypertensive Agents and the Drug Therapy of Hypertension / John A. Oates, Nancy J. Brown 871

34 Pharmacological Treatment of Heart Failure / Henry Ooi, Wilson Colucci 901

35 Antiarrhythmic Drugs / Dan M. Roden 933

36 Drug Therapy for Hypercholesterolemia and Dyslipidemia / Robert W. Mahley, Thomas P. Bersot 971

Sect. VI Drugs Affecting Gastrointestinal Function 1003

37 Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease / Willemijntje A. Hoogerwerf, Pankaj J. Pasricha 1005

38 Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome / Pankaj J. Pasricha 1021

39 Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease / Syed Jafri, Pankaj J. Pasricha 1037

Sect. VII Chemotherapy of Parasitic Infections 1059

Introduction / James W. Tracy, Leslie T. Webster, Jr. 1059

40 Drugs Used in the Chemotherapy of Protozoal Infections: Malaria / James W. Tracy, Leslie T. Webster, Jr. 1069

41 Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections / James W. Tracy, Leslie T. Webster, Jr. 1097

42 Drugs Used in the Chemotherapy of Helminthiasis / James W. Tracy, Leslie T. Webster, Jr. 1121

Sect. VIII Chemotherapy of Microbial Diseases 1141

43 Antimicrobial Agents: General Considerations / Henry F. Chambers 1143

44 Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections / William A. Petri, Jr. 1171

45 Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics / William A. Petri, Jr. 1189

46 Antimicrobial Agents: The Aminoglycosides / Henry F. Chambers 1219

47 Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents / Henry F. Chambers 1239

48 Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy / William A. Petri, Jr. 1273

49 Antimicrobial Agents: Antifungal Agents / John E. Bennett 1295

50 Antimicrobial Agents: Antiviral Agents (Nonretroviral) / Frederick G. Hayden 1313

51 Antimicrobial Agents: Antiretroviral Agents / Stephen P. Raffanti, David W. Haas 1349

Sect. IX Chemotherapy of Neoplastic Diseases 1381

Introduction / Paul Calabresi, Bruce A. Chabner 1381

52 Antineoplastic Agents [et al.] / Bruce A. Chabner, David P. Ryan, Luis Paz-Ares 1389

Sect. X Drugs Used for Immunomodulation 1461

53 Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants / Alan M. Krensky, Terry B. Strom, Jaffrey A. Bluestone 1463

Sect. XI Drugs Acting on the Blood and the Blood-Forming Organs 1485

54 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins / Robert S. Hillman 1487

55 Anticoagulant, Thrombolytic, and Antiplatelet Drugs / Philip W. Majerus, Douglas M. Tollefsen 1519

Sect. XII Hormones and Hormone Antagonists 1539

56 Pituitary Hormones and Their Hypothalamic Releasing Factors / Keith L. Parker, Bernard P. Schimmer 1541

57 Thyroid and Antithyroid Drugs / Alan P. Farwell, Lewis E. Braverman 1563

58 Estrogens and Progestins / David S. Loose-Mitchell, George M. Stancel 1597

59 Androgens / Peter J. Snyder 1635

60 Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones / Bernard P. Schimmer, Keith L. Parker 1649

61 Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas / Stephan N. Davis, Daryl K. Granner 1679

62 Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds / Robert Marcus 1715

Sect. XIII The Vitamins 1745

Introduction / Robert Marcus, Ann M. Coulston 1745

63 Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid / Robert Marcus, Ann M. Coulston 1753

64 Fat-Soluble Vitamins: Vitamins A, K, and E / Robert Marcus, Ann M. Coulston 1773

Sect. XIV Dermatology 1793

65 Dermatological Pharmacology / Eric L. Wyatt, Steven H. Sutter, Lynn A. Drake 1795

Sect. XV Ophthalmology 1819

66 Ocular Pharmacology / Sayoko E. Moroi, Paul R. Lichter 1821

Sect. XVI Toxicology 1849

67 Heavy Metals and Heavy-Metals Antagonists / Curtis D. Klaassen 1851

68 Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides / Curtis D. Klaassen 1877

App. I Principles of Prescription Order Writing and Patient Compliance / Lauralea Edwards, Dan M. Roden 1903

App. II Design and Optimization of Dosage Regimens: Pharmacokinetic Data / Kenneth E. Thummel, Danny D. Shen 1917

Index 2025

Description xxvii, 2148 pages : illustrations ; 26 cm

Series McGraw-Hill international editions

McGraw-Hill international editions

Note Includes bibliographical references and index

Contents Sect. I. General Principles -- Introduction / Alfred Goodman Gilman -- 1. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination / Grant R. Wilkinson -- 2. Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect / Elliott M. Ross and Terry P. Kenakin -- 3. Principles of Therapeutics / Alan S. Nies -- 4. Principles of Toxicology and Treatment of Poisoning / Curtis D. Klaassen -- 5. Gene Therapy / Christopher S. Rogers, Bruce A. Sullenger and Alfred L. George, Jr. -- Sect. II. Drugs Acting at Synaptic and Neuroeffector Junctional Sites -- 6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems / Brian B. Hoffman and Palmer Taylor -- 7. Muscarinic Receptor Agonists and Antagonists / Joan Heller Brown and Palmer Taylor -- 8. Anticholinesterase Agents / Palmer Taylor -- 9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia / Palmer Taylor -- 10. Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists / Brian B. Hoffman -- 11. 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists / Elaine Sanders-Bush and Steven E. Mayer -- Sect. III. Drugs Acting on the Central Nervous System -- 12. Neurotransmission and the Central Nervous System / Floyd E. Bloom -- 13. History and Principles of Anesthesiology / Charles Beattie -- 14. General Anesthetics / Alex S. Evers and C. Michael Crowder -- 15. Local Anesthetics / William A. Catterall and Kenneth Mackie -- 16. Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium / Eric J. Moody, Brett A. Simon and Roger A. Johns -- 17. Hypnotics and Sedatives / Dennis S. Charney, S. John Mihic and R. Adron Harris -- 18. Ethanol / Michael F. Fleming, S. John Mihic and R. Adron Harris -- 19. Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders / Ross J. Baldessarini

Subjects Pharmacology

Chemotherapy

Pharmacology

Drug Therapy

Alt Name Goodman, Louis S. (Louis Sanford), 1906-2000. https://id.oclc.org/worldcat/entity/E39PBJpjd6g9mtQQVcr4Hjjgrq

Hardman, Joel G

Limbird, Lee E

Gilman, Alfred Goodman, 1941-2015. https://id.oclc.org/worldcat/entity/E39PBJqBvMWBVP8c9bw7B4yGHC

Other Titles Pharmacological basis of therapeutics

Goodman and Gilman's the pharmacological basis of therapeutics

Link Online version: Goodman & Gilman's the pharmacological basis of therapeutics. 10th ed. New York : McGraw-Hill, ©2001 (OCoLC)664624094

LC NO RM300 .G644 2001

Nlm No QV 4 G6532 2001

Call # 615.2

Dewey No 615/.7 21

OCLC # 46548349

ISBN 0071354697 (alk. paper)

9780071354691 (alk. paper)

0071124322 (International ed.)

9780071124324 (International ed.)

Isn/Std # (OCoLC)46548349 (OCoLC)47930114 (OCoLC)50214830 (OCoLC)52357454 (OCoLC)55756016 (OCoLC)55794517 (OCoLC)237052106 (OCoLC)316866351 (OCoLC)397244616 (OCoLC)890247997 (OCoLC)890444338 (OCoLC)894130384 (OCoLC)1011925253 (OCoLC)1027868522 (OCoLC)1065308785 (OCoLC)1078022856 (OCoLC)1080766537 (OCoLC)1084966097 (OCoLC)1086251614 (OCoLC)1191296721 (OCoLC)1198539676 (OCoLC)1201570233 (OCoLC)1201611531 (OCoLC)1201836945 (OCoLC)1201852651

LCCN 2001030728

Sect. I	General Principles		1
	Introduction / Alfred Goodman Gilman		1
	1	Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination / Grant R. Wilkinson	3
	2	Pharmacodynamics: Mechanisms of Drug Action and the Relationship Between Drug Concentration and Effect / Elliott M. Ross, Terry P. Kenakin	31
	3	Principles of Therapeutics / Alan S. Nies	45
	4	Principles of Toxicology and Treatment of Poisoning / Curtis D. Klaassen	67
	5	Gene Therapy / Christopher S. Rogers, Bruce A. Sullenger, Alfred L. George, Jr.	81
Sect. II	Drugs Acting at Synaptic and Neuroeffector Junctional Sites		113
	6	Neurotransmission: The Autonomic and Somatic Motor Nervous Systems / Brian B. Hoffman, Palmer Taylor	115
	7	Muscarinic Receptor Agonists and Antagonists / Joan Heller Brown, Palmer Taylor	155
	8	Anticholinesterase Agents / Palmer Taylor	175
	9	Agents Acting at the Neuromuscular Junction and Autonomic Ganglia / Palmer Taylor	193
	10	Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists / Brian B. Hoffman	215
	11	5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists / Elaine Sanders-Bush, Steven E. Mayer	269
Sect. III	Drugs Acting on the Central Nervous System		291
	12	Neurotransmission and the Central Nervous System / Floyd E. Bloom	293
	13	History and Principles of Anesthesiology / Charles Beattie	321
	14	General Anesthetics / Alex S. Evers, C. Michael Crowder	337
	15	Local Anesthetics / William A. Catterall, Kenneth Mackie	367
	16	Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium / Eric J. Moody, Brett A. Simon, Roger A. Johns	385
	17	Hypnotics and Sedatives / Dennis S. Charney, S. John Mihic, R. Adron Harris	399
	18	Ethanol / Michael F. Fleming, S. John Mihic, R. Adron Harris	429
	19	Drugs and the Treatment of Psychiatric Disorders: Depression and Anxiety Disorders / Ross J. Baldessarini	447
	20	Drugs and the Treatment of Psychiatric Disorders: Psychosis and Mania / Ross J. Baldessarini, Frank I. Tarazi	485
	21	Drugs Effective in the Therapy of the Epilepsies / James O. McNamara	521
	22	Treatment of Central Nervous System Degenerative Disorders / David G. Standaert, Anne B. Young	549
	23	Opioid Analgesics / Howard B. Gutstein, Huda Akil	569
	24	Drug Addiction and Drug Abuse / Charles P. O'Brien	621
Sect. IV	Autacoids; Drug Therapy of Inflammation		643
	Introduction / Jason D. Morrow, L. Jackson Roberts II		643
	25	Histamine, Bradykinin, and their Antagonists / Nancy J. Brown, L. Jackson Roberts II	645
	26	Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor / Jason D. Morrow, L. Jackson Roberts II	669
	27	Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout / L. Jackson Roberts II, Jason D. Morrow	687
	28	Drugs Used in the Treatment of Asthma / Bradley J. Undem, Lawrence M. Lichtenstein	733
Sect. V	Drugs Affecting Renal and Cardiovascular Function		755
	29	Diuretics / Edwin K. Jackson	757
	30	Vasopressin and Other Agents Affecting the Renal Conservation of Water / Edwin K. Jackson	789
	31	Renin and Angiotensin / Edwin K. Jackson	809
	32	Drugs Used for the Treatment of Myocardial Ischemia / David M. Kerins, Rose Marie Robertson, David Robertson	843
	33	Antihypertensive Agents and the Drug Therapy of Hypertension / John A. Oates, Nancy J. Brown	871
	34	Pharmacological Treatment of Heart Failure / Henry Ooi, Wilson Colucci	901
	35	Antiarrhythmic Drugs / Dan M. Roden	933
	36	Drug Therapy for Hypercholesterolemia and Dyslipidemia / Robert W. Mahley, Thomas P. Bersot	971
Sect. VI	Drugs Affecting Gastrointestinal Function		1003
	37	Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease / Willemijntje A. Hoogerwerf, Pankaj J. Pasricha	1005
	38	Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome / Pankaj J. Pasricha	1021
	39	Agents Used for Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease / Syed Jafri, Pankaj J. Pasricha	1037
Sect. VII	Chemotherapy of Parasitic Infections		1059
	Introduction / James W. Tracy, Leslie T. Webster, Jr.		1059
	40	Drugs Used in the Chemotherapy of Protozoal Infections: Malaria / James W. Tracy, Leslie T. Webster, Jr.	1069
	41	Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections / James W. Tracy, Leslie T. Webster, Jr.	1097
	42	Drugs Used in the Chemotherapy of Helminthiasis / James W. Tracy, Leslie T. Webster, Jr.	1121
Sect. VIII	Chemotherapy of Microbial Diseases		1141
	43	Antimicrobial Agents: General Considerations / Henry F. Chambers	1143
	44	Antimicrobial Agents: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections / William A. Petri, Jr.	1171
	45	Antimicrobial Agents: Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics / William A. Petri, Jr.	1189
	46	Antimicrobial Agents: The Aminoglycosides / Henry F. Chambers	1219
	47	Antimicrobial Agents: Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents / Henry F. Chambers	1239
	48	Antimicrobial Agents: Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy / William A. Petri, Jr.	1273
	49	Antimicrobial Agents: Antifungal Agents / John E. Bennett	1295
	50	Antimicrobial Agents: Antiviral Agents (Nonretroviral) / Frederick G. Hayden	1313
	51	Antimicrobial Agents: Antiretroviral Agents / Stephen P. Raffanti, David W. Haas	1349
Sect. IX	Chemotherapy of Neoplastic Diseases		1381
	Introduction / Paul Calabresi, Bruce A. Chabner		1381
	52	Antineoplastic Agents [et al.] / Bruce A. Chabner, David P. Ryan, Luis Paz-Ares	1389
Sect. X	Drugs Used for Immunomodulation		1461
	53	Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants / Alan M. Krensky, Terry B. Strom, Jaffrey A. Bluestone	1463
Sect. XI	Drugs Acting on the Blood and the Blood-Forming Organs		1485
	54	Hematopoietic Agents: Growth Factors, Minerals, and Vitamins / Robert S. Hillman	1487
	55	Anticoagulant, Thrombolytic, and Antiplatelet Drugs / Philip W. Majerus, Douglas M. Tollefsen	1519
Sect. XII	Hormones and Hormone Antagonists		1539
	56	Pituitary Hormones and Their Hypothalamic Releasing Factors / Keith L. Parker, Bernard P. Schimmer	1541
	57	Thyroid and Antithyroid Drugs / Alan P. Farwell, Lewis E. Braverman	1563
	58	Estrogens and Progestins / David S. Loose-Mitchell, George M. Stancel	1597
	59	Androgens / Peter J. Snyder	1635
	60	Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones / Bernard P. Schimmer, Keith L. Parker	1649
	61	Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas / Stephan N. Davis, Daryl K. Granner	1679
	62	Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds / Robert Marcus	1715
Sect. XIII	The Vitamins		1745
	Introduction / Robert Marcus, Ann M. Coulston		1745
	63	Water-Soluble Vitamins: The Vitamin B Complex and Ascorbic Acid / Robert Marcus, Ann M. Coulston	1753
	64	Fat-Soluble Vitamins: Vitamins A, K, and E / Robert Marcus, Ann M. Coulston	1773
Sect. XIV	Dermatology		1793
	65	Dermatological Pharmacology / Eric L. Wyatt, Steven H. Sutter, Lynn A. Drake	1795
Sect. XV	Ophthalmology		1819
	66	Ocular Pharmacology / Sayoko E. Moroi, Paul R. Lichter	1821
Sect. XVI	Toxicology		1849
	67	Heavy Metals and Heavy-Metals Antagonists / Curtis D. Klaassen	1851
	68	Nonmetallic Environmental Toxicants: Air Pollutants, Solvents and Vapors, and Pesticides / Curtis D. Klaassen	1877
App. I	Principles of Prescription Order Writing and Patient Compliance / Lauralea Edwards, Dan M. Roden		1903
App. II	Design and Optimization of Dosage Regimens: Pharmacokinetic Data / Kenneth E. Thummel, Danny D. Shen		1917
	Index		2025