(Translated by https://www.hiragana.jp/)
February 25, 2019 19.02d en NCI Thesaurus, a controlled vocabulary in support of NCI administrative and scientific activities. Produced by the Enterprise Vocabulary System (EVS), a project by the NCI Center for Biomedical Informatics and Information Technology. National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A. A1 Conceptual Entity Role Has Domain Role_Has_Domain Role_Has_Domain An association that specifies the parent of the branch encompassing a role's domain. Role_Has_Domain Role_Has_Domain PT NCI An association that specifies the parent of the branch encompassing a role's domain. NCI A10 Conceptual Entity Has CDRH Parent Has_CDRH_Parent Has_CDRH_Parent An association created to allow the source CDRH to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source. Has_CDRH_Parent Has_CDRH_Parent PT NCI An association created to allow the source CDRH to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source. NCI A11 Conceptual Entity Has_NICHD_Parent Has_NICHD_Parent An association created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are a contributing source. Has_NICHD_Parent Has_NICHD_Parent PT NCI An association created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are a contributing source. NCI A12 Conceptual Entity Has Data Element Has_Data_Element Has_Data_Element An association created to relate a data element concept to the codelist term that is used to bundle its subset of valid value concepts. Has_Data_Element Has_Data_Element PT NCI An association created to relate a data element concept to the codelist term that is used to bundle its subset of valid value concepts. NCI A13 Conceptual Entity Related_To_Genetic_Biomarker Related_To_Genetic_Biomarker An association that indicates that a finding or lab test is related to a gene, possibly through a variant or product. Related_To_Genetic_Biomarker An association that indicates that a finding or lab test is related to a gene, possibly through a variant or product. NCI Related_To_Genetic_Biomarker PT NCI A14 Conceptual Entity Neoplasm_Has_Special_Category Neoplasm_Has_Special_Category An association that indicates that a neoplastic disease can have the characteristics defined by a Neoplasm by Special Category concept. Neoplasm_Has_Special_Category Neoplasm_Has_Special_Category PT NCI An association that indicates that a neoplastic disease can have the characteristics defined by a Neoplasm by Special Category concept. NCI A15 Conceptual Entity Has_CTCAE_5_Parent Has_CTCAE_5_Parent An association created to allow the source CTCAE 5.0 to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which CTCAE is the contributing source. Has_CTCAE_5_Parent Has_CTCAE_5_Parent PT NCI An association created to allow the source CTCAE 5.0 to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which CTCAE is the contributing source. NCI A16 Conceptual Entity Has_INC_Parent Has_INC_Parent An association created to allow the source INC to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source. Has_INC_Parent Has_INC_Parent PT NCI An association created to allow the source INC to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source. NCI A2 Conceptual Entity Role Has Range Role_Has_Range Role_Has_Range An association that specifies the parent of the branch encompassing the role's range. Role_Has_Range Role_Has_Range PT NCI An association that specifies the parent of the branch encompassing the role's range. NCI A3 Conceptual Entity Role Has Parent Role_Has_Parent Role_Has_Parent An association that specifies that a role exists as part of a role hierarchy and specifies the role's parent, the role that this role specializes. Role_Has_Parent Role_Has_Parent PT NCI An association that specifies that a role exists as part of a role hierarchy and specifies the role's parent, the role that this role specializes. NCI A4 Conceptual Entity Qualifier Applies To Qualifier_Applies_To Qualifier_Applies_To An association that indicates the property or association that the qualifier is to be used with. Qualifier_Applies_To Qualifier_Applies_To PT NCI An association that indicates the property or association that the qualifier is to be used with. NCI A5 Conceptual Entity Has Salt Form Has_Salt_Form Has_Salt_Form An association that connects the salt form of a drug with its free acid or free base. USAGE NOTE: A salt form of a drug consists of 2 parts, one acidic and one basic group that are readily disassociated in liquid phase. Salt forms are either salts of strong acids and basic drugs (e.g. Atropine Sulfate, Cetirizine Hydrochloride) or salts of strong bases and acidic drugs (Allopurinol Sodium). This association is usually used in conjunction with Has_Free_Acid_Or_Base_Form. Has_Salt_Form Has_Salt_Form PT NCI An association that connects the salt form of a drug with its free acid or free base. NCI A6 Conceptual Entity Has Free Acid Or Base Form Has_Free_Acid_Or_Base_Form Has_Free_Acid_Or_Base_Form An association that connects the salt form of a drug with its free acid or free base. The free acid or base is responsible for the drug's therapeutic effect. Hence, the salt form of a drug has the same mechanism of action as the free acid or base form. Has_Free_Acid_Or_Base_Form Has_Free_Acid_Or_Base_Form PT NCI An association that connects the salt form of a drug with its free acid or free base. NCI A7 Conceptual Entity Has Target Has_Target Has_Target An association that connects a drug or other agent to a clinically intended, molecular-scale target. The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. The effect is most often direct, as defined at a molecular scale, but may also be indirect and/or defined at a larger scale. Has_Target Has_Target PT NCI An association that connects a drug or other agent to a clinically intended, molecular-scale target. The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. The effect is most often direct, as defined at a molecular scale, but may also be indirect and/or defined at a larger scale. NCI A8 Conceptual Entity Concept Is In Subset Concept_In_Subset Concept_In_Subset An association that connects the concept defining a particular terminology subset with concepts that belong to this subset. Concept_In_Subset Concept_In_Subset PT NCI An association that connects the concept defining a particular terminology subset with concepts that belong to this subset. NCI A9 Conceptual Entity Is Related To Endogenous Product Is_Related_To_Endogenous_Product Is_Related_To_Endogenous_Product An association that is asserted when there is a relationship or association between the therapeutic moiety and the endogenous gene product. Is_Related_To_Endogenous_Product Is_Related_To_Endogenous_Product PT NCI An association that is asserted when there is a relationship or association between the therapeutic moiety and the endogenous gene product. NCI P380 Definition_Review_Date true Definition_Review_Date P379 Definition_Reviewer_Name true Definition_Reviewer_Name NHC0 code code A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus. true code code PT NCI A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus. NCI P100 Conceptual Entity OMIM Number OMIM_Number OMIM_Number A property representing the accession number for a Protein or Gene within the OMIM database. OMIM_Number OMIM_Number PT NCI A property representing the accession number for a Protein or Gene within the OMIM database. NCI P101 Conceptual Entity Homologous Gene Homologous_Gene Homologous_Gene A property representing genes from other organisms that are similar in sequence and provide insight to the gene's function. Homologous_Gene Homologous_Gene PT NCI A property representing genes from other organisms that are similar in sequence and provide insight to the gene's function. NCI P102 Conceptual Entity GenBank Accession Number GenBank_Accession_Number GenBank_Accession_Number A property representing the accession number for a Gene within the GenBank database. GenBank_Accession_Number GenBank_Accession_Number PT NCI A property representing the accession number for a Gene within the GenBank database. NCI P106 Conceptual Entity Semantic Type Semantic_Type Semantic_Type A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network. In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS. Semantic_Type Semantic_Type PT NCI A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network. NCI P107 Conceptual Entity Display Name Display_Name Display Name Display_Name A property representing an alternative Preferred Name for use in some NCI systems. Display_Name Display Name SY NCI Display_Name PT NCI A property representing an alternative Preferred Name for use in some NCI systems. NCI P108 Conceptual Entity Preferred Name Preferred_Name Preferred Name Preferred Term Preferred_Name A property representing the word or phrase that NCI uses by preference to refer to the concept. Preferred_Name Preferred Name SY NCI Preferred Term SY NCI Preferred_Name PT NCI A property representing the word or phrase that NCI uses by preference to refer to the concept. NCI P167 Conceptual Entity Image Link Image_Link Image_Link A property representing a link to an image in an external database. Image_Link Image_Link PT NCI A property representing a link to an image in an external database. NCI P171 Conceptual Entity PubMedID Primary Reference PubMedID_Primary_Reference PubMedID_Primary_Reference A property used to provide a primary reference for descriptions of an NCI Thesaurus concept. PubMedID_Primary_Reference PubMedID_Primary_Reference PT NCI A property used to provide a primary reference for descriptions of an NCI Thesaurus concept. NCI P175 Conceptual Entity NSC Number NSC_Number NSC_Code NSC_Number NSC_Number_Property A property representing a numeric identifier for substances submitted to the National Cancer Institute (NCI) for testing and evaluation. It is named after the Cancer Chemotherapy National Service Center (CCNSC), created in 1955, which originally ran the testing program and assigned these numbers. The testing program and repository is now run by the NCI Developmental Therapeutics Program (DTP). Assignment of NSC numbers was never done in a way that would guarantee one and only one NSC number would be assigned to a particular substance. NSC_Code NSC_Code SY NCI NSC_Number PT NCI NSC_Number_Property SY NCI A property representing a numeric identifier for substances submitted to the National Cancer Institute (NCI) for testing and evaluation. It is named after the Cancer Chemotherapy National Service Center (CCNSC), created in 1955, which originally ran the testing program and assigned these numbers. The testing program and repository is now run by the NCI Developmental Therapeutics Program (DTP). Assignment of NSC numbers was never done in a way that would guarantee one and only one NSC number would be assigned to a particular substance. NCI P200 Conceptual Entity OLD PARENT OLD_PARENT OLD_PARENT A property used to store the name of parent concepts present at the time a concept was retired. OLD_PARENT OLD_PARENT PT NCI A property used to store the name of parent concepts present at the time a concept was retired. NCI P201 Conceptual Entity OLD CHILD OLD_CHILD OLD_CHILD A property used to store the name of children concepts present at the time a concept was retired. OLD_CHILD OLD_CHILD PT NCI A property used to store the name of children concepts present at the time a concept was retired. NCI P203 Conceptual Entity OLD KIND OLD_KIND OLD_KIND Used to store the name of the concept's kind at the time a concept was retired. OLD_KIND OLD_KIND PT NCI Used to store the name of the concept's kind at the time a concept was retired. NCI P204 Conceptual Entity OLD ROLE OLD_ROLE OLD_ROLE A property used to store the name and value of asserted roles present at the time a concept was retired. OLD_ROLE OLD_ROLE PT NCI A property used to store the name and value of asserted roles present at the time a concept was retired. NCI P205 Conceptual Entity OLD STATE OLD_STATE OLD_STATE A property used to store the state of a concept, primitive or defined, at the time a concept was retired. OLD_STATE OLD_STATE PT NCI A property used to store the state of a concept, primitive or defined, at the time a concept was retired. NCI P207 Conceptual Entity UMLS CUI UMLS_CUI UMLS_CUI A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept. UMLS_CUI UMLS_CUI PT NCI A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept. NCI P208 Conceptual Entity NCI Metathesaurus CUI NCI_META_CUI NCI_META_CUI A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS). NCI_META_CUI NCI_META_CUI PT NCI A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS). NCI P210 Conceptual Entity CAS Registry Number CAS_Registry CAS_Registry A property representing the Chemical Abstracts Service number for a Chemical or Drug. CAS_Registry CAS_Registry PT NCI A property representing the Chemical Abstracts Service number for a Chemical or Drug. NCI P211 Conceptual Entity GO Annotation GO_Annotation GO_Annotation A property that contains information that can be used for cross-referencing to relevant entries in the Gene Ontology (GO) database including term name, code, and evidence code. GO_Annotation GO_Annotation PT NCI A property that contains information that can be used for cross-referencing to relevant entries in the Gene Ontology (GO) database including term name, code, and evidence code. NCI P215 Conceptual Entity KEGG ID KEGG_ID KEGG_ID A property representing the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information. KEGG_ID KEGG_ID PT NCI A property representing the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information. NCI P216 Conceptual Entity BioCarta ID BioCarta_ID BioCarta_ID A property representing the BioCarta ID code for a pathway. It can be used to link a BioCarta pathway reference to the primary pathway information. BioCarta_ID BioCarta_ID PT NCI A property representing the BioCarta ID code for a pathway. It can be used to link a BioCarta pathway reference to the primary pathway information. NCI P302 Conceptual Entity Accepted Therapeutic Use For Accepted_Therapeutic_Use_For Accepted_Therapeutic_Use_For A property representing a disease or condition for which this drug is an accepted treatment. Used in the Drug, Food, Chemical or Biomedical Material branch. Accepted_Therapeutic_Use_For Accepted_Therapeutic_Use_For PT NCI A property representing a disease or condition for which this drug is an accepted treatment. Used in the Drug, Food, Chemical or Biomedical Material branch. NCI P310 Conceptual Entity Concept Status Concept_Status Concept_Status A property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used. Concept_Status Concept_Status PT NCI A property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used. NCI P315 Conceptual Entity SNP ID SNP_ID SNP_ID A property representing the dbSNP id number for the genetic polymorphism due to base substitutions. SNP_ID SNP_ID PT NCI A property representing the dbSNP id number for the genetic polymorphism due to base substitutions. NCI P316 Conceptual Entity Relative Enzyme Activity Relative_Enzyme_Activity Relative_Enzyme_Activity A property representing drug efficacy of the allelic product. Relative_Enzyme_Activity Relative_Enzyme_Activity PT NCI A property representing drug efficacy of the allelic product. NCI P317 Conceptual Entity FDA Table FDA_Table FDA_Table A property used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency. FDA_Table FDA_Table PT NCI A property used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency. NCI P319 Conceptual Entity FDA UNII Code FDA_UNII_Code FDA_UNII_Code A property representing the FDA Unique Ingredient Identifier, a key component of the federal drug information model. FDA_UNII_Code FDA_UNII_Code PT NCI A property representing the FDA Unique Ingredient Identifier, a key component of the federal drug information model. NCI P320 Conceptual Entity OID OID OID A property representing a globally unique identifier standardized by the International Organization for Standardization (ISO) for naming computational objects consistently and unambiguously. Object identifiers (OID) are assigned by a regulatory association. The NCI Thesaurus OID was asssigned by and is registered with the HL7 OID Registry and is the following string: 2.16.840.1.113883.3.26.1.1. OID OID PT NCI A property representing a globally unique identifier standardized by the International Organization for Standardization (ISO) for naming computational objects consistently and unambiguously. Object identifiers (OID) are assigned by a regulatory association. The NCI Thesaurus OID was asssigned by and is registered with the HL7 OID Registry and is the following string: 2.16.840.1.113883.3.26.1.1. NCI P321 Conceptual Entity EntrezGene ID EntrezGene_ID EntrezGene_ID GeneID Locus_ID A property representing the accession number for a Gene within the Entrez Gene database. This property has replaced Locus_ID. EntrezGene_ID EntrezGene_ID PT NCI GeneID SY NCI Locus_ID SY NCI A property representing the accession number for a Gene within the Entrez Gene database. NCI P322 Conceptual Entity Contributing Source Contributing_Source Contributing_Source A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake. Contributing_Source Contributing_Source PT NCI A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake. NCI P325 Conceptual Entity [source] Definition ALT_DEFINITION ALT_DEFINITION A property representing the English language definition of a concept from a source other than NCI. ALT_DEFINITION ALT_DEFINITION PT NCI A property representing the English language definition of a concept from a source other than NCI. NCI P329 Conceptual Entity PDQ Open Trial Search ID PDQ_Open_Trial_Search_ID PDQ_Open_Trial_Search_ID A property representing the identifier used by NCI's Cancer.gov Web site to retrieve PDQ Clinical Trials data for open trials involving specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only open trials will be retrieved. PDQ_Open_Trial_Search_ID PDQ_Open_Trial_Search_ID PT NCI A property representing the identifier used by NCI's Cancer.gov Web site to retrieve PDQ Clinical Trials data for open trials involving specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only open trials will be retrieved. NCI P330 Conceptual Entity PDQ Closed Trial Search ID PDQ_Closed_Trial_Search_ID PDQ_Closed_Trial_Search_ID A property representing the identifier used by NCI's Cancer.gov web site to retrieve PDQ Clinical Trials data for closed trials that involved specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only closed trials will be retrieved. PDQ_Closed_Trial_Search_ID PDQ_Closed_Trial_Search_ID PT NCI A property representing the identifier used by NCI's Cancer.gov web site to retrieve PDQ Clinical Trials data for closed trials that involved specific clinical trials agents. While the identifier is the same for both open and closed trials two properties are used to support requirements of the current browser interface, as well as the possibility of providing values where only closed trials will be retrieved. NCI P331 Conceptual Entity NCBI Taxon ID NCBI_Taxon_ID NCBI_Taxon_ID A property that is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon. NCBI_Taxon_ID NCBI_Taxon_ID PT NCI A property that is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon. NCI P332 Conceptual Entity MGI Accession ID MGI_Accession_ID MGI_Accession_ID A property representing the identifier used by Jackson Laboratories Mouse Genome Informatics group to label inbred mouse strains maintained by Jackson Laboratory and other things such as mouse genes and alleles. MGI_Accession_ID MGI_Accession_ID PT NCI A property representing the identifier used by Jackson Laboratories Mouse Genome Informatics group to label inbred mouse strains maintained by Jackson Laboratory and other things such as mouse genes and alleles. NCI P333 Conceptual Entity Use For Use_For Use_For A property representing a term that had been used in a coding system and then subsumed by the given NCIt concept. Use_For Use_For PT NCI A property representing a term that had been used in a coding system and then subsumed by the given NCIt concept. NCI P334 Conceptual Entity ICD-O-3 Code ICD-O-3_Code ICD-O-3_Code A property representing the matching ICD-O-3 code for the NCI Thesaurus concept. ICD-O-3_Code ICD-O-3_Code PT NCI A property representing the matching ICD-O-3 code for the NCI Thesaurus concept. NCI P350 Conceptual Entity Chemical Formula Chemical_Formula CRCH Chemical Formula Chemical_Formula A property representing a concise expression about the atoms that constitute a particular chemical compound. Chemical_Formula Chemical Formula PT CRCH Chemical_Formula PT NCI A property representing a concise expression about the atoms that constitute a particular chemical compound. NCI P351 Conceptual Entity US FNB Recommends Intake US_Recommended_Intake CRCH A property indicating that the Food and Nutrition Board of the National Academy of Science has established an average daily intake for this nutrient that is sufficient to meet the nutritional requirements of most individuals in the general U.S. population. Recommended Intake Required_Intake US_Recommended_Intake US_Recommended_Intake A property indicating that the Food and Nutrition Board of the National Academy of Science has established an average daily intake for this nutrient that is sufficient to meet the nutritional requirements of most individuals in the general U.S. population. CRCH Recommended Intake PT CRCH Required_Intake SY NCI US_Recommended_Intake PT NCI P352 Conceptual Entity Tolerable Level Tolerable_Level CRCH A property indicating that the Food and Nutrition Board of the National Academy of Science has established a highest level of daily intake for this food component that is likely to pose no risk of adverse health effects for almost all individuals in the general U.S. population. Tolerable Level Tolerable_Level Tolerable_Level A property indicating that the Food and Nutrition Board of the National Academy of Science has established a highest level of daily intake for this food component that is likely to pose no risk of adverse health effects for almost all individuals in the general U.S. population. CRCH Tolerable Level PT CRCH Tolerable_Level PT NCI P353 Conceptual Entity INFOODS Tag Name INFOODS CRCH INFOODS A property representing uppercase abbreviations assigned by the International Network of Food Data Systems. INFOODS INFOODS PT CRCH INFOODS PT NCI A property representing uppercase abbreviations assigned by the International Network of Food Data Systems. NCI P354 Conceptual Entity USDA ID USDA_ID CRCH USDA ID USDA_ID A property representing a numeric ID assignment by United States Department of Agriculture. USDA_ID USDA ID PT CRCH USDA_ID PT NCI A property representing a numeric ID assignment by United States Department of Agriculture. NCI P355 Conceptual Entity Unit Used Unit CRCH Unit A property representing the unit of measure in which a nutrient or food component is typically expressed, ex., gram (g), minigram (mg), microgram (mcg), joule, or kilojoule. Unit Unit PT CRCH Unit PT NCI A property representing the unit of measure in which a nutrient or food component is typically expressed, ex., gram (g), minigram (mg), microgram (mcg), joule, or kilojoule. NCI P356 Conceptual Entity Is An Essential Amino Acid Essential_Amino_Acid Essential_Amino_Acid A property used to indicate that an amino acid is essential and must be included in the diet. Essential_Amino_Acid Essential_Amino_Acid PT NCI A property used to indicate that an amino acid is essential and must be included in the diet. NCI P357 Conceptual Entity Is An Essential Fatty Acid Essential_Fatty_Acid CRCH Essential Fatty Acid Essential_Fatty_Acid A property used to indicate a fatty acid that is not efficiently synthesized by humans and must be included in the diet. Essential_Fatty_Acid Essential Fatty Acid PT CRCH Essential_Fatty_Acid PT NCI A property used to indicate a fatty acid that is not efficiently synthesized by humans and must be included in the diet. NCI P358 Conceptual Entity Is A Nutrient Nutrient CRCH A property indicating that a food component must be taken into the body preformed and in sufficient quantity to meet the body's needs for growth, reproduction and/or maintenance of health. Nutrient Nutrient A property indicating that a food component must be taken into the body preformed and in sufficient quantity to meet the body's needs for growth, reproduction and/or maintenance of health. CRCH Nutrient PT CRCH Nutrient PT NCI P359 Conceptual Entity Is A Micronutrient Micronutrient CRCH A property indicating a class of food components required for proper health and that are typically consumed in microgram or milligram amounts. mg Micronutrient Micronutrient A property indicating a class of food components required for proper health and that are typically consumed in microgram or milligram amounts. CRCH Micronutrient PT CRCH Micronutrient PT NCI P360 Conceptual Entity Macronutrient Macronutrient CRCH A property indicating a class of food components that contribute energy to the diet and that are typically consumed in multi-gram amounts. g Macronutrient Macronutrient A property indicating a class of food components that contribute energy to the diet and that are typically consumed in multi-gram amounts. CRCH Macronutrient PT CRCH Macronutrient PT NCI P361 Conceptual Entity Extensible_List Extensible_List List Extensible A property representing the ability to extend the set of values in a particular list. Extensible_List Extensible_List PT NCI List Extensible SY NCI A property representing the ability to extend the set of values in a particular list. NCI P362 Conceptual Entity miRBase_ID miRBase_ID A property representing the accession number for an miRNA within the Sanger miRBase database. miRBase_ID miRBase_ID PT NCI A property representing the accession number for an miRNA within the Sanger miRBase database. NCI P363 Conceptual Entity Neoplastic Status Neoplastic_Status FDA Neoplastic_Status A property representing the morphologic, clinical, and genetic profile of a neoplastic growth that defines it as benign, malignant, or of uncertain cancerous potential. Neoplastic_Status Neoplastic_Status PT NCI A property representing the morphologic, clinical, and genetic profile of a neoplastic growth that defines it as benign, malignant, or of uncertain cancerous potential. NCI P364 Conceptual Entity OLD_ASSOCIATION OLD_ASSOCIATION A property used to store the name and value of associations present at the time a concept was retired. OLD_ASSOCIATION OLD_ASSOCIATION PT NCI A property used to store the name and value of associations present at the time a concept was retired. NCI P365 OLD_SOURCE_ASSOCIATION OLD_SOURCE_ASSOCIATION A property used to temporarily store the name and value of associations present at the time a concept is premerged or preretired, where the target of the association is the concept being retired. Values stored in this property are restored as associations on the source concept if the merge or retire is rejected. OLD_SOURCE_ASSOCIATION OLD_SOURCE_ASSOCIATION PT NCI A property used to temporarily store the name and value of associations present at the time a concept is premerged or preretired, where the target of the association is the concept being retired. Values stored in this property are restored as associations on the source concept if the merge or retire is rejected. NCI P366 Conceptual Entity Legacy Concept Name Legacy Concept Name A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding. true Legacy_Concept_Name Legacy Concept Name PT NCI A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding. NCI P367 Conceptual Entity PID_ID PID_ID A property representing the NCI/Nature Pathway Interaction Database (PID) code for a pathway. It can be used by the NCIt Browser to link a pathway concept to the source pathway information. PID_ID PID_ID PT NCI A property representing the NCI/Nature Pathway Interaction Database (PID) code for a pathway. It can be used by the NCIt Browser to link a pathway concept to the source pathway information. NCI P368 Conceptual Entity CHEBI_ID CHEBI_ID A property representing that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest (CHEBI) database. CHEBI_ID CHEBI_ID PT NCI A property representing that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest (CHEBI) database. NCI P369 Conceptual Entity HGNC_ID HGNC_ID HUGO_ID A property representing that a concept in the 'Gene' branch of the NCI thesaurus maps to a HUGO Gene Nomenclature Committee (HGNC) certified gene. HGNC_ID HGNC_ID PT NCI HUGO_ID SY NCI A property representing that a concept in the 'Gene' branch of the NCI thesaurus maps to a HUGO Gene Nomenclature Committee (HGNC) certified gene. NCI P371 Conceptual Entity NICHD_Hierarchy_Term NICHD NICHD_Hierarchy_Term A property representing a term chosen by NICHD to be used in the representation of the NICHD hierarchy. NICHD_Hierarchy_Term NICHD_Hierarchy_Term PT NCI A property representing a term chosen by NICHD to be used in the representation of the NICHD hierarchy. NCI P372 Conceptual Entity Publish_Value_Set Publish_Value_Set A property representing whether a value set is ready for publication in the browser. Publish_Value_Set Publish_Value_Set PT NCI A property representing whether a value set is ready for publication in the browser. NCI P375 Conceptual Entity Maps_To Maps_To A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms. Maps_To Maps_To PT NCI A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms. NCI P376 Conceptual Entity Term_Browser_Value_Set_Description Term_Browser_Value_Set_Description A property used to house the text on the introductory page on the NCI Term Browser for the Value Set named by a concept when that text differs from the DEFINITION for that concept. Term_Browser_Value_Set_Description Term_Browser_Value_Set_Description PT NCI A property used to house the text on the introductory page on the NCI Term Browser for the Value Set named by a concept when that text differs from the DEFINITION for that concept. NCI P377 def-definition def-definition P378 def-source A property representing the organization that is the supplier or owner of each DEFINITION or ALT_DEFINITION associated with a concept. true def-source A property representing the organization that is the supplier or owner of each DEFINITION or ALT_DEFINITION associated with a concept. NCI P381 attr A property indicating that some of the information in a DEFINITION or ALT_DEFINITION was derived from a source other than the def-source. attr A property indicating that some of the information in a DEFINITION or ALT_DEFINITION was derived from a source other than the def-source. NCI P382 term-name term-name P383 term-group A property representing a two or three character abbreviation that indicates the nature of each FULL_SYN term associated with a concept. (e.g., PT=Preferred Term; SY=Synonym) true term-group P384 term-source NCI A property representing the organization that is the supplier or owner of each FULL_SYN term. true term-source P385 source-code A property representing an identifier associated with a FULL_SYN term that is supplied by the term-source. source-code A property representing an identifier associated with a FULL_SYN term that is supplied by the term-source. NCI P386 subsource-name A property indicating that a subgroup within the term-source is the supplier or owner of a FULL_SYN term. subsource-name A property indicating that a subgroup within the term-source is the supplier or owner of a FULL_SYN term. NCI P387 go-id A property representing a unique zero-padded seven digit identifier supplied by the Gene Ontology (GO) that has no inherent meaning or relation to the position of the term in GO and is prefixed by "GO:". true go-id A property representing a unique zero-padded seven digit identifier supplied by the Gene Ontology (GO) that has no inherent meaning or relation to the position of the term in GO and is prefixed by "GO:". NCI http://www.geneontology.org/page/ontology-structure P388 go-term go-term P389 go-evi A property representing a three letter code that indicates the type of supporting evidence for each GO_Annotation associated with a concept. true go-evi A property representing a three letter code that indicates the type of supporting evidence for each GO_Annotation associated with a concept. NCI http://www.geneontology.org/page/guide-go-evidence-codes P390 go-source A property representing the organization that is the supplier or owner of each GO_Annotation associated with a concept. true go-source A property representing the organization that is the supplier or owner of each GO_Annotation associated with a concept. NCI P391 source-date A property representing the date each GO_Annotation was added to a concept. true source-date A property representing the date each GO_Annotation was added to a concept. NCI P392 Target_Term A property representing the term in an outside source that has been mapped to a term within the NCI Thesaurus. Target_Term A property representing the term in an outside source that has been mapped to a term within the NCI Thesaurus. NCI P393 Relationship_to_Target A property representing the relationship of the NCI Thesaurus (NCIt) concept to the term from the outside source. There are four possibilities: 1) Has Synonym: the two terms are synonymous; 2) Broader Than: the NCIt concept is broader than the mapped (target) term; 3) Narrower Than: the NCIt concept is narrower than the mapped (target) term; 4) Related To: the NCIt concept is somehow related to the mapped (target) term. true Relationship_to_Target A property representing the relationship of the NCI Thesaurus (NCIt) concept to the term from the outside source. There are four possibilities: 1) Has Synonym: the two terms are synonymous; 2) Broader Than: the NCIt concept is broader than the mapped (target) term; 3) Narrower Than: the NCIt concept is narrower than the mapped (target) term; 4) Related To: the NCIt concept is somehow related to the mapped (target) term. NCI P394 Target_Term_Type A property representing the term type designation in the mapped (target) database. true Target_Term_Type A property representing the term type designation in the mapped (target) database. NCI P395 Target_Code NCI A property representing the code assigned to the target term in the mapped (target) database. Some databases may not have codes. true Target_Code A property representing the code assigned to the target term in the mapped (target) database. Some databases may not have codes. NCI P396 Target_Terminology A property representing the name of the terminology to which the NCI Thesaurus term is being mapped. true Target_Terminology A property representing the name of the terminology to which the NCI Thesaurus term is being mapped. NCI P90 Conceptual Entity Term & Source Data FULL_SYN FULL_SYN Synonym with Source Data A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software. FULL_SYN FULL_SYN PT NCI Synonym with Source Data SY NCI A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software. NCI P92 Conceptual Entity Subsource Subsource Subsource A property used by MMHCC to identify the source of various mouse disease concepts. Subsource Subsource PT NCI A property used by MMHCC to identify the source of various mouse disease concepts. NCI P93 Conceptual Entity Swiss Prot Swiss_Prot Swiss_Prot A property representing the accession number for a protein within the Swiss-Prot database. Swiss_Prot Swiss_Prot PT NCI A property representing the accession number for a protein within the Swiss-Prot database. NCI P96 Conceptual Entity Gene Encodes Product Gene_Encodes_Product Gene_Encodes_Product A property representing the protein or RNA product expressed by a gene. This represents the reciprocal relationship of the role Gene_Product_Encoded_by_Gene Gene_Encodes_Product Gene_Encodes_Product PT NCI A property representing the protein or RNA product expressed by a gene. NCI P97 Conceptual Entity Definition DEFINITION DEFINITION A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. DEFINITION DEFINITION PT NCI A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software. NCI P98 Conceptual Entity DesignNote DesignNote DesignNote A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept. DesignNote DesignNote PT NCI A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept. NCI xRef Source A property representing the name of the organization to which an NCI Thesaurus concept is being linked to by cross reference. xRef Source A property representing the name of the organization to which an NCI Thesaurus concept is being linked to by cross reference. NCI xRef A property representing a reference to an identical or very similar object in another database. xRef A property representing a reference to an identical or very similar object in another database. NCI http://www.geneontology.org/page/ontology-structure comment label Concept_Pending_Approval Deprecated_Concept Header_Concept Obsolete_Concept Provisional_Concept Retired_Concept ACC BRIDG CBDD CDISC CDISC-GLOSS COH CPTAC CRCH CTCAE CTEP CTRP CareLex EDQM-HC FDA GAIA HL7 ICH INC MedDRA NCCN NCPDP NDC NICHD PI-RADS UCUM NCI Drug Dictionary NA No Yes Device Problem Code (Appendix B) Dosage Form (C-DRG-00201) Marketing Category (C-DRG-0935) Package Type (C-DRG-00907) Patient Code (Appendix B) Plant Part (C-DRG-00924) Potency (C-DRG-00501) Route of Administration (C-DRG-00301) SPL Color (C-DRG-00927) SPL DEA Schedule (C-DRG-0933) SPL Flavor (C-DRG-0934) SPL Shape (C-DRG-00929) Benign Malignant Precancerous Uncertain Malignant Potential Undetermined Alliance COG CTRP Biomarker Abstraction DCP Data Commons Framework Duke Sarcoma Project GDC NCCN NCI CCR PopSci SIG Rave SEER SEER CAN TCGA caDSR General No Yes Broader Than Has Synonym Narrower Than Related To Acquired Abnormality Activity Age Group Amino Acid Sequence Amino Acid, Peptide, or Protein Amphibian Anatomical Abnormality Anatomical Structure Animal Antibiotic Archaeon Bacterium Behavior Biologic Function Biologically Active Substance Biomedical Occupation or Discipline Biomedical or Dental Material Bird Body Location or Region Body Part, Organ, or Organ Component Body Space or Junction Body Substance Body System Carbohydrate Sequence Cell Cell Component Cell Function Cell or Molecular Dysfunction Chemical Chemical Viewed Functionally Chemical Viewed Structurally Classification Clinical Attribute Clinical Drug Conceptual Entity Congenital Abnormality Daily or Recreational Activity Diagnostic Procedure Disease or Syndrome Drug Delivery Device Educational Activity Element, Ion, or Isotope Embryonic Structure Entity Environmental Effect of Humans Enzyme Eukaryote Event Experimental Model of Disease Family Group Finding Fish Food Fully Formed Anatomical Structure Functional Concept Fungus Gene or Genome Genetic Function Geographic Area Governmental or Regulatory Activity Group Group Attribute Hazardous or Poisonous Substance Health Care Activity Health Care Related Organization Hormone Human Human-caused Phenomenon or Process Idea or Concept Immunologic Factor Indicator, Reagent, or Diagnostic Aid Individual Behavior Injury or Poisoning Inorganic Chemical Intellectual Product Laboratory Procedure Laboratory or Test Result Language Machine Activity Mammal Manufactured Object Medical Device Mental Process Mental or Behavioral Dysfunction Molecular Biology Research Technique Molecular Function Molecular Sequence Natural Phenomenon or Process Neoplastic Process Nucleic Acid, Nucleoside, or Nucleotide Nucleotide Sequence Occupation or Discipline Occupational Activity Organ or Tissue Function Organic Chemical Organism Organism Attribute Organism Function Organization Pathologic Function Patient or Disabled Group Pharmacologic Substance Phenomenon or Process Physical Object Physiologic Function Plant Population Group Professional Society Professional or Occupational Group Qualitative Concept Quantitative Concept Receptor Regulation or Law Reptile Research Activity Research Device Self-help or Relief Organization Sign or Symptom Social Behavior Spatial Concept Substance Temporal Concept Therapeutic or Preventive Procedure Tissue Vertebrate Virus Vitamin TVS_ADaM_Component TVS_CDASH_Component TVS_CDISC_ADaM TVS_CDISC_CDASH TVS_CDISC_Clinical_Classification TVS_CDISC_Component TVS_CDISC_Functional_Test TVS_CDISC_Glossary TVS_CDISC_Protocol TVS_CDISC_Questionnaire TVS_CDISC_SDTM TVS_CDISC_SEND TVS_CDRH_GUID_Component TVS_CareLex TVS_Clinical_Classification_Component TVS_DICOM_Component TVS_EDQM-HC TVS_EDQM-HC_Component TVS_FDA_Device TVS_FDA_Device_Component TVS_FDA_PQCMC TVS_FDA_PQCMC_Component TVS_FDA_PQCMC_Test_Category TVS_FDA_PQCMC_Test_Category_Component TVS_FDA_QM TVS_FDA_QM_Component TVS_FDA_SPL TVS_FDA_SPL_Biz_Ops TVS_FDA_SPL_Biz_Ops_Component TVS_FDA_SPL_Blood TVS_FDA_SPL_Blood_Component TVS_FDA_SPL_Blood_Tissue TVS_FDA_SPL_Blood_Tissue_Component TVS_FDA_SPL_Component TVS_FDA_SPL_REMS TVS_FDA_SPL_REMS_Component TVS_FDA_SPL_Tissue TVS_FDA_SPL_Tissue_Component TVS_FDA_UNII TVS_FDA_eManufacturing_Component TVS_Functional_Test_Component TVS_GAIA TVS_GAIA_Component TVS_ICSR TVS_ICSR_Component TVS_IDMP_Component TVS_NCI_CTS-API_Disease_Category TVS_NCI_CTS-API_Disease_Category_Component TVS_NCI_Component TVS_NCI_Drug_Component TVS_NCI_Neoplasm_Component TVS_NCPDP TVS_NCPDP_Component TVS_NICHD TVS_NICHD_Component TVS_PIRADS_Component TVS_Protocol_Component TVS_Questionnaire_Component TVS_SDTM_Component TVS_SEND_Component TVS_UCUM_Component TVS_eCTD_Component LLT PT SY EDQM-HC GAIA ICD10 2016 ICD10CM 2017 ICD9CM 2014 MedDRA MedDRA 18.1 MedDRA 20.1 MedDRA 22.0 ACC BIOCARTA BRIDG CADSR CBDD CDISC CDISC-GLOSS CRCH CSP2000 CSP2003 CTCAE CTCAE 3.0 CTCAE 5.0 CTEP CareLex DICOM EDQM-HC FDA GAIA ICD03 INC KEGG MMHCC MSH2001 MSH2002_06_01 MSH2003_2003_05_12 NCI NCI-DEFCURATOR NCI-GLOSS NICHD SPL CGAP NCBI NCI AB AD AQ AQS BR CA2 CA3 CN CNU CS DN FB HD LLT PT SN SY ACC ANSI BIOCARTA BRIDG CADSR CBDD CDC CDISC CDISC-GLOSS CPTAC CRCH CTCAE CTCAE 3.0 CTCAE 5.0 CTEP CTRM CTRP CareLex DCP DICOM DTP EDQM-HC FDA GAIA GENC HGNC HL7 ICH INC JAX KEGG MTH MedDRA NCI NCI-GLOSS NCPDP NDC NICHD PI-RADS PID SEER UCUM IMDRF R100 Conceptual Entity Has Associated Anatomic Site Disease_Has_Associated_Anatomic_Site Disease_Has_Associated_Anatomic_Site A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. The role, Disease_Has_Associated_Anatomic_Site, is more general than the role, Disease_Has_Primary_Anatomic_Site. Furthermore, when viewed with the role, Disease_Has_Metastatic_Anatomic_Site, there emerges a role hierarchy, where one role specializes the meaning of another, more general role. Roles relating disease to anatomy start with a general assertion of association, often at very high level (e.g. Skin Disorder and Skin), and then add more specific primary/metastatic associations where appropriate for more specific concepts. Disease_Has_Associated_Anatomic_Site Disease_Has_Associated_Anatomic_Site PT NCI A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R101 Conceptual Entity Has Primary Anatomic Site Disease_Has_Primary_Anatomic_Site Disease_Has_Primary_Anatomic_Site A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. This role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site. Disease_Has_Primary_Anatomic_Site Disease_Has_Primary_Anatomic_Site PT NCI A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R102 Conceptual Entity Has Metastatic Anatomic Site Disease_Has_Metastatic_Anatomic_Site Disease_Has_Metastatic_Anatomic_Site A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. The role can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site. Disease_Has_Metastatic_Anatomic_Site Disease_Has_Metastatic_Anatomic_Site PT NCI A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R103 Conceptual Entity Has Normal Tissue Origin Disease_Has_Normal_Tissue_Origin Disease_Has_Normal_Tissue_Origin A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. This non-defining role represents non-essential characteristics which are true in some, but not all, cases, yet have an association frequent enough to be of interest. Disease_Has_Normal_Tissue_Origin Disease_Has_Normal_Tissue_Origin PT NCI A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R104 Conceptual Entity Has Normal Cell Origin Disease_Has_Normal_Cell_Origin Disease_Has_Normal_Cell_Origin A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_Has_Normal_Cell_Origin Disease_Has_Normal_Cell_Origin PT NCI A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R105 Conceptual Entity Has Abnormal Cell Disease_Has_Abnormal_Cell Disease_Has_Abnormal_Cell A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. Disease_Has_Abnormal_Cell Disease_Has_Abnormal_Cell PT NCI A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. NCI R106 Conceptual Entity Has Molecular Abnormality Disease_Has_Molecular_Abnormality Disease_Has_Molecular_Abnormality A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_Has_Molecular_Abnormality Disease_Has_Molecular_Abnormality PT NCI A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI R107 Conceptual Entity Has Cytogenetic Abnormality Disease_Has_Cytogenetic_Abnormality Disease_Has_Cytogenetic_Abnormality A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_Has_Cytogenetic_Abnormality Disease_Has_Cytogenetic_Abnormality PT NCI A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI R108 Conceptual Entity Has Finding Disease_Has_Finding Disease_Has_Finding A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'. Disease_Has_Finding Disease_Has_Finding PT NCI A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'. NCI R110 Conceptual Entity Is Grade Disease_Is_Grade Disease_Is_Grade A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively. Disease_Is_Grade Disease_Is_Grade PT NCI A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively. NCI R111 Conceptual Entity May Have Normal Tissue Origin Disease_May_Have_Normal_Tissue_Origin Disease_May_Have_Normal_Tissue_Origin A role used to represent that a normal tissue type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_May_Have_Normal_Tissue_Origin Disease_May_Have_Normal_Tissue_Origin PT NCI A role used to represent that a normal tissue type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R112 Conceptual Entity May Have Normal Cell Origin Disease_May_Have_Normal_Cell_Origin Disease_May_Have_Normal_Cell_Origin A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_May_Have_Normal_Cell_Origin Disease_May_Have_Normal_Cell_Origin PT NCI A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R113 Conceptual Entity May Have Abnormal Cell Disease_May_Have_Abnormal_Cell Disease_May_Have_Abnormal_Cell A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. Disease_May_Have_Abnormal_Cell Disease_May_Have_Abnormal_Cell PT NCI A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. NCI R114 Conceptual Entity May Have Cytogenetic Abnormality Disease_May_Have_Cytogenetic_Abnormality Disease_May_Have_Cytogenetic_Abnormality A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_May_Have_Cytogenetic_Abnormality Disease_May_Have_Cytogenetic_Abnormality PT NCI A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI R115 Conceptual Entity May Have Finding Disease_May_Have_Finding Disease_May_Have_Finding A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'. Disease_May_Have_Finding Disease_May_Have_Finding PT NCI A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'. NCI R116 Conceptual Entity May Have Associated Disease Disease_May_Have_Associated_Disease Disease_May_Have_Associated_Disease A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'. Disease_May_Have_Associated_Disease Disease_May_Have_Associated_Disease PT NCI A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'. NCI R122 Conceptual Entity Is Metabolized By Enzyme Chemical_Or_Drug_Is_Metabolized_By_Enzyme Chemical_Or_Drug_Is_Metabolized_By_Enzyme A role used to specify that an enzyme is directly responsible for metabolizing a chemical or drug into an active form, inactive form, or both. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively. Chemical_Or_Drug_Is_Metabolized_By_Enzyme Chemical_Or_Drug_Is_Metabolized_By_Enzyme PT NCI A role used to specify that an enzyme is directly responsible for metabolizing a chemical or drug into an active form, inactive form, or both. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively. NCI R123 Conceptual Entity Has Component Chemotherapy_Regimen_Has_Component Chemotherapy_Regimen_Has_Component A role used to specify the component agents which are used in a particular chemotherapy regimen or agent combination. The domain and the range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Drug, Food, Chemical or Biomedical Material', respectively. Chemotherapy_Regimen_Has_Component Chemotherapy_Regimen_Has_Component PT NCI A role used to specify the component agents which are used in a particular chemotherapy regimen or agent combination. The domain and the range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Drug, Food, Chemical or Biomedical Material', respectively. NCI R124 Conceptual Entity Has Mechanism Of Action Chemical_Or_Drug_Has_Mechanism_Of_Action Chemical_Or_Drug_Has_Mechanism_Of_Action A role used to imply the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. Chemical_Or_Drug_Has_Mechanism_Of_Action Chemical_Or_Drug_Has_Mechanism_Of_Action PT NCI A role used to imply the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. NCI R125 Conceptual Entity Has Physiologic Effect Chemical_Or_Drug_Has_Physiologic_Effect Chemical_Or_Drug_Has_Physiologic_Effect A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. Chemical_Or_Drug_Has_Physiologic_Effect Chemical_Or_Drug_Has_Physiologic_Effect PT NCI A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. NCI R126 Conceptual Entity Has Associated Disease Disease_Has_Associated_Disease Disease_Has_Associated_Disease A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'. Disease_Has_Associated_Disease Disease_Has_Associated_Disease PT NCI A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'. NCI R130 Conceptual Entity Is Element In Pathway Gene_Is_Element_In_Pathway Gene_Is_Element_In_Pathway A role used to assert a relationship between a gene and a biochemical pathway in which its encoded gene product(s) participate. This relationship is used only when gene has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene' and 'Biochemical Pathway', respectively. In NCI Thesaurus, pathways are derived from BioCarta and KEGG and are associated with genes and proteins that comprise these pathways. Gene_Is_Element_In_Pathway A role used to assert a relationship between a gene and a biochemical pathway in which its encoded gene product(s) participate. This relationship is used only when gene has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene' and 'Biochemical Pathway', respectively. NCI Gene_Is_Element_In_Pathway PT NCI R131 Conceptual Entity Is Element In Pathway Gene_Product_Is_Element_In_Pathway Gene_Product_Is_Element_In_Pathway A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively. In NCI Thesaurus, pathways are derived from BioCarta and KEGG and are associated with genes and proteins that comprise these pathways. Gene_Product_Is_Element_In_Pathway Gene_Product_Is_Element_In_Pathway PT NCI A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively. NCI R132 Conceptual Entity Has Abnormality Gene_Has_Abnormality Gene_Has_Abnormality A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively. Gene_Has_Abnormality Gene_Has_Abnormality PT NCI A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively. NCI R133 Conceptual Entity Has Abnormality Gene_Product_Has_Abnormality Gene_Product_Has_Abnormality A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively. Gene_Product_Has_Abnormality Gene_Product_Has_Abnormality PT NCI A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively. NCI R135 Conceptual Entity Excludes Primary Anatomic Site Disease_Excludes_Primary_Anatomic_Site Disease_Excludes_Primary_Anatomic_Site A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_Excludes_Primary_Anatomic_Site Disease_Excludes_Primary_Anatomic_Site PT NCI A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R136 Conceptual Entity Excludes Metastatic Anatomic Site Disease_Excludes_Metastatic_Anatomic_Site Disease_Excludes_Metastatic_Anatomic_Site A specializing role which may be used to override Disease_Has_ Metastatic_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_Excludes_Metastatic_Anatomic_Site Disease_Excludes_Metastatic_Anatomic_Site PT NCI A specializing role which may be used to override Disease_Has_ Metastatic_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R137 Conceptual Entity Excludes Normal Tissue Origin Disease_Excludes_Normal_Tissue_Origin Disease_Excludes_Normal_Tissue_Origin A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_Excludes_Normal_Tissue_Origin Disease_Excludes_Normal_Tissue_Origin PT NCI A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R138 Conceptual Entity Excludes Normal Cell Origin Disease_Excludes_Normal_Cell_Origin Disease_Excludes_Normal_Cell_Origin A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. Disease_Excludes_Normal_Cell_Origin Disease_Excludes_Normal_Cell_Origin PT NCI A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively. NCI R139 Conceptual Entity Excludes Abnormal Cell Disease_Excludes_Abnormal_Cell Disease_Excludes_Abnormal_Cell A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. Disease_Excludes_Abnormal_Cell Disease_Excludes_Abnormal_Cell PT NCI A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively. NCI R140 Conceptual Entity Excludes Molecular Abnormality Disease_Excludes_Molecular_Abnormality Disease_Excludes_Molecular_Abnormality A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_Excludes_Molecular_Abnormality Disease_Excludes_Molecular_Abnormality PT NCI A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI R141 Conceptual Entity Excludes Cytogenetic Abnormality Disease_Excludes_Cytogenetic_Abnormality Disease_Excludes_Cytogenetic_Abnormality A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_Excludes_Cytogenetic_Abnormality Disease_Excludes_Cytogenetic_Abnormality PT NCI A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI R142 Conceptual Entity Excludes Finding Disease_Excludes_Finding Disease_Excludes_Finding A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'. Disease_Excludes_Finding Disease_Excludes_Finding PT NCI A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'. NCI R145 Conceptual Entity Has Physical Location Gene_Has_Physical_Location Gene_Has_Physical_Location A role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. The standard for the numbering system is that assigned by the Human Genome Consortium and found at Entrez Gene. The role is considered as supplementary to the role Gene_In Chromosomal_Location Gene_Has_Physical_Location Gene_Has_Physical_Location PT NCI A role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. NCI R146 Conceptual Entity Affects Gene Product Chemical_Or_Drug_Affects_Gene_Product Chemical_Or_Drug_Affects_Gene_Product A role used to assert that a gene product is the target of a therapeutic agent. The role implies a direct interaction between the product and the therapeutic agent but it does not specify the type of association (e.g., involvement, interference, inhibition or cleavage). The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively. Chemical_Or_Drug_Affects_Gene_Product Chemical_Or_Drug_Affects_Gene_Product PT NCI A role used to assert that a gene product is the target of a therapeutic agent. The role implies a direct interaction between the product and the therapeutic agent but it does not specify the type of association (e.g., involvement, interference, inhibition or cleavage). The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively. NCI R150 Conceptual Entity Affects Abnormal Cell Chemical_Or_Drug_Affects_Abnormal_Cell Chemical_Or_Drug_Affects_Abnormal_Cell A role used to establish the relationship between a therapeutic agent and an abnormal cell type associated with a disease condition. By pointing to abnormal cells, the therapeutic target of a drug can be more clearly conveyed. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Abnormal Cell', respectively. Chemical_Or_Drug_Affects_Abnormal_Cell Chemical_Or_Drug_Affects_Abnormal_Cell PT NCI A role used to establish the relationship between a therapeutic agent and an abnormal cell type associated with a disease condition. By pointing to abnormal cells, the therapeutic target of a drug can be more clearly conveyed. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Abnormal Cell', respectively. NCI R153 Conceptual Entity Has Abnormality Allele_Has_Abnormality Allele_Has_Abnormality A specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively. Allele_Has_Abnormality Allele_Has_Abnormality PT NCI A specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively. NCI R155 Conceptual Entity In Chromosomal Location Allele_In_Chromosomal_Location Allele_In_Chromosomal_Location A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. Allele_In_Chromosomal_Location Allele_In_Chromosomal_Location PT NCI A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. NCI R156 Conceptual Entity Absent From Wild-type Chromosomal Location Allele_Absent_From_Wild-type_Chromosomal_Location Allele_Absent_From_Wild-type_Chromosomal_Location A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to negate an inherited role relationship that is asserted between the parent gene class and a chromosomal location when an allele has moved (e.g., translocation, inversion, etc.). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. Allele_Absent_From_Wild-type_Chromosomal_Location Allele_Absent_From_Wild-type_Chromosomal_Location PT NCI A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to negate an inherited role relationship that is asserted between the parent gene class and a chromosomal location when an allele has moved (e.g., translocation, inversion, etc.). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. NCI R158 Conceptual Entity Plays Altered Role In Process Allele_Plays_Altered_Role_In_Process Allele_Plays_Altered_Role_In_Process A specializing role which may be used for an allele whose encoded product functions differently (qualitatively or quantitatively) from the function asserted on its parent. It specializes the function of the wild type gene/gene product. The domain and range for this role are 'Gene' and 'Biological Process', respectively. Allele_Plays_Altered_Role_In_Process Allele_Plays_Altered_Role_In_Process PT NCI A specializing role which may be used for an allele whose encoded product functions differently (qualitatively or quantitatively) from the function asserted on its parent. It specializes the function of the wild type gene/gene product. The domain and range for this role are 'Gene' and 'Biological Process', respectively. NCI R159 Conceptual Entity Has Activity Allele_Has_Activity Allele_Has_Activity A role used to assert the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range for this role are 'Gene' and 'Property or Attribute', respectively. Allele_Has_Activity Allele_Has_Activity PT NCI A role used to assert the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range for this role are 'Gene' and 'Property or Attribute', respectively. NCI R160 Conceptual Entity Plays Role In Metabolism Of Chemical Or Drug Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug A role used to assert a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range for this role are 'Gene' and 'Drug, Food, Chemical or Biomedical Material', respectively. Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug PT NCI A role used to assert a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range for this role are 'Gene' and 'Drug, Food, Chemical or Biomedical Material', respectively. NCI R163 Conceptual Entity Has Target Anatomy Procedure_Has_Target_Anatomy Procedure_Has_Target_Anatomy A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_Has_Target_Anatomy Procedure_Has_Target_Anatomy PT NCI A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R165 Conceptual Entity Has Imaged Anatomy Procedure_Has_Imaged_Anatomy Procedure_Has_Imaged_Anatomy A role used to assert a relationship between an imaging procedure and its target anatomy, specifically that a particular procedure always involves imaging the specified anatomy. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_Has_Imaged_Anatomy Procedure_Has_Imaged_Anatomy PT NCI A role used to assert a relationship between an imaging procedure and its target anatomy, specifically that a particular procedure always involves imaging the specified anatomy. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R166 Conceptual Entity May Have Excised Anatomy Procedure_May_Have_Excised_Anatomy Procedure_May_Have_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_May_Have_Excised_Anatomy Procedure_May_Have_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R167 Conceptual Entity Has Excised Anatomy Procedure_Has_Excised_Anatomy Procedure_Has_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_Has_Excised_Anatomy Procedure_Has_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R168 Conceptual Entity May Have Partially Excised Anatomy Procedure_May_Have_Partially_Excised_Anatomy Procedure_May_Have_Partially_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_May_Have_Partially_Excised_Anatomy Procedure_May_Have_Partially_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R169 Conceptual Entity Has Partially Excised Anatomy Procedure_Has_Partially_Excised_Anatomy Procedure_Has_Partially_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_Has_Partially_Excised_Anatomy Procedure_Has_Partially_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R170 Conceptual Entity May Have Completely Excised Anatomy Procedure_May_Have_Completely_Excised_Anatomy Procedure_May_Have_Completely_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_May_Have_Completely_Excised_Anatomy Procedure_May_Have_Completely_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R171 Conceptual Entity Has Completely Excised Anatomy Procedure_Has_Completely_Excised_Anatomy Procedure_Has_Completely_Excised_Anatomy A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. Procedure_Has_Completely_Excised_Anatomy Procedure_Has_Completely_Excised_Anatomy PT NCI A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively. NCI R172 Conceptual Entity Has Accepted Use For Disease Regimen_Has_Accepted_Use_For_Disease Regimen_Has_Accepted_Use_For_Disease A role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively. Regimen_Has_Accepted_Use_For_Disease Regimen_Has_Accepted_Use_For_Disease PT NCI A role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively. NCI R173 Conceptual Entity Cytogenetic_Abnormality_Involves_Chromosome Cytogenetic_Abnormality_Involves_Chromosome A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations. Cytogenetic_Abnormality_Involves_Chromosome Cytogenetic_Abnormality_Involves_Chromosome PT NCI A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations. NCI R174 Conceptual Entity Disease_Mapped_To_Chromosome Disease_Mapped_To_Chromosome A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations. Disease_Mapped_To_Chromosome Disease_Mapped_To_Chromosome PT NCI A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome. It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations. NCI R175 Conceptual Entity Gene_Involved_In_Pathogenesis_Of_Disease Gene_Involved_In_Pathogenesis_Of_Disease A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively. Gene_Involved_In_Pathogenesis_Of_Disease Gene_Involved_In_Pathogenesis_Of_Disease PT NCI A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively. NCI R176 Conceptual Entity Disease_Mapped_To_Gene Disease_Mapped_To_Gene A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively. Disease_Mapped_To_Gene Disease_Mapped_To_Gene PT NCI A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively. NCI R177 Conceptual Entity Molecular_Abnormality_Involves_Gene Molecular_Abnormality_Involves_Gene A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively. Molecular_Abnormality_Involves_Gene Molecular_Abnormality_Involves_Gene PT NCI A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively. NCI R178 Conceptual Entity Gene_Mutant_Encodes_Gene_Product_Sequence_Variation Gene_Mutant_Encodes_Gene_Product_Sequence_Variation A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively. Gene_Mutant_Encodes_Gene_Product_Sequence_Variation Gene_Mutant_Encodes_Gene_Product_Sequence_Variation PT NCI A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively. NCI R179 Conceptual Entity Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively. Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant PT NCI A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively. NCI R180 Conceptual Entity Procedure_Has_Target_Disease Procedure_Has_Target_Disease A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state. The domain and range for this role are 'Activity' and 'Disease, Disorder or Finding', respectively. Procedure_Has_Target_Disease Procedure_Has_Target_Disease PT NCI A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state. The domain and range for this role are 'Activity' and 'Disease, Disorder or Finding', respectively. NCI R181 Conceptual Entity Procedure_Uses_Manufactured_Object Procedure_Uses_Manufactured_Object A role used to assert that a procedure or technical method requires use of specific artifacts or pieces of equipment. The domain and range for this role are 'Activity' and 'Manufactured Object', respectively. Procedure_Uses_Manufactured_Object Procedure_Uses_Manufactured_Object PT NCI A role used to assert that a procedure or technical method requires use of specific artifacts or pieces of equipment. The domain and range for this role are 'Activity' and 'Manufactured Object', respectively. NCI R182 Conceptual Entity Gene_Product_Variant_Of_Gene_Product Gene_Product_Variant_Of_Gene_Product A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively. Gene_Product_Variant_Of_Gene_Product Gene_Product_Variant_Of_Gene_Product PT NCI A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively. NCI R23 Conceptual Entity Has Associated Cell Type EO_Disease_Has_Associated_Cell_Type EO_Disease_Has_Associated_Cell_Type A role used to specify the associated cell type of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively. EO_Disease_Has_Associated_Cell_Type EO_Disease_Has_Associated_Cell_Type PT NCI A role used to specify the associated cell type of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively. NCI R24 Conceptual Entity Maps To Human Disease EO_Disease_Maps_To_Human_Disease EO_Disease_Maps_To_Human_Disease A role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role are 'Experimental Organism Diagnosis' and 'Disease, Disorder or Finding', respectively. EO_Disease_Maps_To_Human_Disease EO_Disease_Maps_To_Human_Disease PT NCI A role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role are 'Experimental Organism Diagnosis' and 'Disease, Disorder or Finding', respectively. NCI R25 Conceptual Entity Has Associated EO Anatomy EO_Disease_Has_Associated_EO_Anatomy EO_Disease_Has_Associated_EO_Anatomy A role used to specify the general site, structure or system where a pathological process is located in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively. EO_Disease_Has_Associated_EO_Anatomy EO_Disease_Has_Associated_EO_Anatomy PT NCI A role used to specify the general site, structure or system where a pathological process is located in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively. NCI R26 Conceptual Entity Has Property Or Attribute EO_Disease_Has_Property_Or_Attribute EO_Disease_Has_Property_Or_Attribute A role used to specify the clinical behavior, or other characteristic, of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Property or Attribute', respectively. EO_Disease_Has_Property_Or_Attribute EO_Disease_Has_Property_Or_Attribute PT NCI A role used to specify the clinical behavior, or other characteristic, of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Property or Attribute', respectively. NCI R27 Conceptual Entity Part Of Conceptual_Part_Of Conceptual_Part_Of A role used to indicate that a conceptual entity is a sub-entity of another conceptual entity. Both the domain and the range for this role are 'Conceptual Entity'. Conceptual_Part_Of Conceptual_Part_Of PT NCI A role used to indicate that a conceptual entity is a sub-entity of another conceptual entity. Both the domain and the range for this role are 'Conceptual Entity'. NCI R28 Conceptual Entity Has Initiator Process Biological_Process_Has_Initiator_Process Biological_Process_Has_Initiator_Process A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'. Biological_Process_Has_Initiator_Process Biological_Process_Has_Initiator_Process PT NCI A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'. NCI R29 Conceptual Entity Has Result Chemical Or Drug Biological_Process_Has_Result_Chemical_Or_Drug Biological_Process_Has_Result_Chemical_Or_Drug A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively. Biological_Process_Has_Result_Chemical_Or_Drug Biological_Process_Has_Result_Chemical_Or_Drug PT NCI A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively. NCI R30 Conceptual Entity Has Associated Location Biological_Process_Has_Associated_Location Biological_Process_Has_Associated_Location A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively. Biological_Process_Has_Associated_Location Biological_Process_Has_Associated_Location PT NCI A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively. NCI R31 Conceptual Entity Has Result Anatomy Biological_Process_Has_Result_Anatomy Biological_Process_Has_Result_Anatomy A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively. Biological_Process_Has_Result_Anatomy Biological_Process_Has_Result_Anatomy PT NCI A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively. NCI R32 Conceptual Entity Has Initiator Chemical Or Drug Biological_Process_Has_Initiator_Chemical_Or_Drug Biological_Process_Has_Initiator_Chemical_Or_Drug A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively. Biological_Process_Has_Initiator_Chemical_Or_Drug Biological_Process_Has_Initiator_Chemical_Or_Drug PT NCI A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively. NCI R34 Conceptual Entity Has Result Biological Process Biological_Process_Has_Result_Biological_Process Biological_Process_Has_Result_Biological_Process A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'. Biological_Process_Has_Result_Biological_Process Biological_Process_Has_Result_Biological_Process PT NCI A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'. NCI R35 Conceptual Entity Is Part Of Process Biological_Process_Is_Part_Of_Process Biological_Process_Is_Part_Of_Process A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'. Biological_Process_Is_Part_Of_Process Biological_Process_Is_Part_Of_Process PT NCI A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'. NCI R36 Conceptual Entity Is Biomarker Type Gene_Is_Biomarker_Type Gene_Is_Biomarker_Type A role used to designate the type of biomarker a gene is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene' and 'Diagnostic or Prognostic Factor', respectively. Gene_Is_Biomarker_Type Gene_Is_Biomarker_Type PT NCI A role used to designate the type of biomarker a gene is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene' and 'Diagnostic or Prognostic Factor', respectively. NCI R37 Conceptual Entity Plays Role In Process Gene_Plays_Role_In_Process Gene_Plays_Role_In_Process A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively. Gene_Plays_Role_In_Process Gene_Plays_Role_In_Process PT NCI A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively. NCI R38 Conceptual Entity Associated With Disease Gene_Associated_With_Disease Gene_Associated_With_Disease A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively. Gene_Associated_With_Disease Gene_Associated_With_Disease PT NCI A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively. NCI R39 Conceptual Entity A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively. Gene_Is_Biomarker_Of A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively. NCI R40 Conceptual Entity In Chromosomal Location Gene_In_Chromosomal_Location Gene_In_Chromosomal_Location A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. Gene_In_Chromosomal_Location Gene_In_Chromosomal_Location PT NCI A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively. NCI R41 Conceptual Entity Found In Organism Gene_Found_In_Organism Gene_Found_In_Organism A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively. Currently, we only model human genes, but this role has obvious utility in future, if other organisms are modeled as well. Gene_Found_In_Organism Gene_Found_In_Organism PT NCI A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively. NCI R42 Conceptual Entity Is Biomarker Type Gene_Product_Is_Biomarker_Type Gene_Product_Is_Biomarker_Type A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively. Gene_Product_Is_Biomarker_Type Gene_Product_Is_Biomarker_Type PT NCI A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively. NCI R44 Conceptual Entity Has Chemical Classification Gene_Product_Has_Chemical_Classification Gene_Product_Has_Chemical_Classification A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'. The role was originally intended for protein structure tagging (e.g., Phosphoprotein, Lipoprotein). Was extended to also tag for Membrane Protein, Protein Complex Subunit, etc. Gene_Product_Has_Chemical_Classification Gene_Product_Has_Chemical_Classification PT NCI A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'. NCI R45 Conceptual Entity Has Organism Source Gene_Product_Has_Organism_Source Gene_Product_Has_Organism_Source A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively. Gene_Product_Has_Organism_Source Gene_Product_Has_Organism_Source PT NCI A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively. NCI R46 Conceptual Entity Has Associated Anatomy Gene_Product_Has_Associated_Anatomy Gene_Product_Has_Associated_Anatomy A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. Gene_Product_Has_Associated_Anatomy Gene_Product_Has_Associated_Anatomy PT NCI A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. NCI R47 Conceptual Entity Is Biomarker Of Gene_Product_Is_Biomarker_Of Gene_Product_Is_Biomarker_Of A role used to indicate that presence of a gene product may contribute to clinical diagnosis, treatment selection, or prediction of clinical outcome. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively. This role does not imply a cause and effect. Gene_Product_Is_Biomarker_Of Gene_Product_Is_Biomarker_Of PT NCI A role used to indicate that presence of a gene product may contribute to clinical diagnosis, treatment selection, or prediction of clinical outcome. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively. NCI R48 Conceptual Entity Malfunction Associated With Disease Gene_Product_Malfunction_Associated_With_Disease Gene_Product_Malfunction_Associated_With_Disease A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively. Gene_Product_Malfunction_Associated_With_Disease Gene_Product_Malfunction_Associated_With_Disease PT NCI A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively. NCI R49 Conceptual Entity Expressed In Tissue Gene_Product_Expressed_In_Tissue Gene_Product_Expressed_In_Tissue A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. This information is often useful to researchers. However, we no longer curate this information and now favor linking out to externally curated databases. Source database for the link has yet to be decided. Gene_Product_Expressed_In_Tissue Gene_Product_Expressed_In_Tissue PT NCI A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. NCI R50 Conceptual Entity Has Structural Domain Or Motif Gene_Product_Has_Structural_Domain_Or_Motif Gene_Product_Has_Structural_Domain_Or_Motif A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. We no longer curate this information and now favor linking out to externally curated databases. The source database for the link has yet to be decided. Gene_Product_Has_Structural_Domain_Or_Motif Gene_Product_Has_Structural_Domain_Or_Motif PT NCI A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively. NCI R51 Conceptual Entity Is Physical Part Of Gene_Product_Is_Physical_Part_Of Gene_Product_Is_Physical_Part_Of A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'. Gene_Product_Is_Physical_Part_Of Gene_Product_Is_Physical_Part_Of PT NCI A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'. NCI R52 Conceptual Entity Has Biochemical Function Gene_Product_Has_Biochemical_Function Gene_Product_Has_Biochemical_Function A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'. Gene_Product_Has_Biochemical_Function Gene_Product_Has_Biochemical_Function PT NCI A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'. NCI R53 Conceptual Entity Plays Role In Biological Process Gene_Product_Plays_Role_In_Biological_Process Gene_Product_Plays_Role_In_Biological_Process A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively. Considered by most researchers to be essential, definitional information about a gene product. Gene_Product_Plays_Role_In_Biological_Process Gene_Product_Plays_Role_In_Biological_Process PT NCI A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively. NCI R54 Conceptual Entity Encoded By Gene Gene_Product_Encoded_By_Gene Gene_Product_Encoded_By_Gene A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively. The reciprocal relationship is represented in the property Gene_Encodes_Product Gene_Product_Encoded_By_Gene Gene_Product_Encoded_By_Gene PT NCI A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively. NCI R66 Conceptual Entity Plays Role In Biological Process Chemical_Or_Drug_Plays_Role_In_Biological_Process Chemical_Or_Drug_Plays_Role_In_Biological_Process A role used to assert that an active ingredient of a drug or chemical agent influences a biological process. The role implies a direct association with a target biological molecule or complex involved in the process. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. to be deleted Chemical_Or_Drug_Plays_Role_In_Biological_Process Chemical_Or_Drug_Plays_Role_In_Biological_Process PT NCI A role used to assert that an active ingredient of a drug or chemical agent influences a biological process. The role implies a direct association with a target biological molecule or complex involved in the process. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively. NCI R72 Conceptual Entity Affects Cell Type Or Tissue Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue A role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively. Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue PT NCI A role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively. NCI R81 Conceptual Entity Has Location Anatomic_Structure_Has_Location Anatomic_Structure_Has_Location A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'. Anatomic_Structure_Has_Location Anatomic_Structure_Has_Location PT NCI A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'. NCI R82 Conceptual Entity Is Physical Part Of Anatomic_Structure_Is_Physical_Part_Of Anatomic_Structure_Is_Physical_Part_Of A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'. Anatomic_Structure_Is_Physical_Part_Of Anatomic_Structure_Is_Physical_Part_Of PT NCI A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'. NCI R88 Conceptual Entity Is Stage Disease_Is_Stage Disease_Is_Stage A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively. Disease_Is_Stage Disease_Is_Stage PT NCI A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively. NCI R89 Conceptual Entity May Have Molecular Abnormality Disease_May_Have_Molecular_Abnormality Disease_May_Have_Molecular_Abnormality A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. Disease_May_Have_Molecular_Abnormality Disease_May_Have_Molecular_Abnormality PT NCI A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively. NCI C1000 Amino Acid, Peptide, or Protein Pharmacologic Substance Recombinant Amphiregulin C1514768 Recombinant_Amphiregulin AR CRDGF KAF Recombinant Amphiregulin A recombinant form of amphiregulin, a member of the heparin-binding epidermal growth factor (EGF) family. Endogenous amphiregulin is an autocrine growth factor, and binds to the EGF receptor. Overexpressed in several cancer cell types, endogenous amphiregulin may contribute to tumor cell proliferation and metastasis. (NCI04) Recombinant Amphiregulin AR AB NCI CRDGF AB NCI KAF AB NCI Recombinant Amphiregulin PT NCI A recombinant form of amphiregulin, a member of the heparin-binding epidermal growth factor (EGF) family. Endogenous amphiregulin is an autocrine growth factor, and binds to the EGF receptor. Overexpressed in several cancer cell types, endogenous amphiregulin may contribute to tumor cell proliferation and metastasis. (NCI04) NCI C10000 Therapeutic or Preventive Procedure Cyclophosphamide/Fluoxymesterone/Mitolactol/Prednisone/Tamoxifen C0279323 Obsolete_Concept Cyclophosphamide_Fluoxymesterone_Mitolactol_Prednisone_Tamoxifen CD(P)TH CTX/DBD/FXM/PRED/TMX Cyclophosphamide/Fluoxymesterone/Mitolactol/Prednisone/Tamoxifen Cyclophosphamide/Fluoxymesterone/Mitolactol/Prednisone/Tamoxifen CD(P)TH AB NCI CTX/DBD/FXM/PRED/TMX AB NCI Cyclophosphamide/Fluoxymesterone/Mitolactol/Prednisone/Tamoxifen PT NCI C100000 Therapeutic or Preventive Procedure Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction-Stable-Over 12 Hours From Symptom Onset C3272245 CDISC A percutaneous coronary intervention is necessary for a myocardial infarction that presents with ST segment elevation and the subject does not have recurrent or persistent symptoms, symptoms of heart failure or ventricular arrhythmia. The presentation is past twelve hours since onset of symptoms. PERCUTANEOUS CORONARY INTERVENTION (PCI) FOR ST ELEVATION MYOCARDIAL INFARCTION (STEMI) (STABLE, >12 HRS FROM SYMPTOM ONSET) Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction-Stable-Over 12 Hours From Symptom Onset A percutaneous coronary intervention is necessary for a myocardial infarction that presents with ST segment elevation and the subject does not have recurrent or persistent symptoms, symptoms of heart failure or ventricular arrhythmia. The presentation is past twelve hours since onset of symptoms. (ACC) Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction-Stable-Over 12 Hours From Symptom Onset