Abstract
HLA CLASS II molecules have a crucial role in the immune response to antigens. We have isolated two new class II-like complementary DNA sequences, RING6 and RING7, which map between the HLA-DNA and -DOB loci. They are novel members of the immunoglobulin gene family which may have diverged before the duplications that gave rise to the main class II loci. The RING6 and RING7 genes seem to encode
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References
Cho, S., Attaya, M. & Monaco, J. J. Nature 353, 573–576 (1991).
Hanson, I. & Trowsdale, J. Immunogenetics 34, 5–11 (1991).
Hood, L., Kronenberg, M. & Hunkapiller, T. Cell 40, 225–229 (1985).
Kelly, A. & Trowsdale, J. Nucleic Acids Res. 13, 1607–1621 (1985).
Brown, J. H. et al. Nature 332, 845–850 (1988).
Lindahl, K. F. et al. Cold Spring Harb. Symp. Quant. Biol. 24, 563–569 (1989).
Shawar, S. M., Cook, R. G., Rodgers, J. R. & Rich, R. R. J. exp. Med. 171, 897–912 (1990).
Trowsdale, J. et al. Nature 348, 741–744 (1990).
Blanck, G. & Strominger, J. L. J. Immun. 141, 1734–1738 (1988).
Ragoussis, J. et al. Proc. natn. Acad. Sci. U.S.A. 88, 3753–3757 (1991).
Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning, A Laboratory Manual (Cold Spring Harbor laboratory, Cold Spring Harbor, New York, 1989).
Trowsdale, J. & Kelly, A. P. EMB0 J. 4, 2231–2237 (1985).
Tonnelle, C., DeMars, R. & Long, E. O. EMBO J. 4, 2839–2847 (1985).
Klein, J. Natural History of the Major Histocompatibility Complex (Wiley, New Ypork, 1986).
Guessow, D. et al. J. Immun. 139, 3122–3138 (1987).
O'Sullivan, D. M., Larhammar, D., Wilson, C., Peterson, P. A. & Quaranta, V. Proc. natn. Acad. Sci. U.S.A. 83, 4484–4488 (1986).
Bankier, A. T., Weston, K. M. & Narrell, B. G. Meth. Enzym. 1555, 51–93 (1987).
Staden, R. Comput. Applic. Biosci. 6, 387–393 (1990).
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Kelly, A., Monaco, J., Cho, S. et al. A new human HLA class II-related locus, DM. Nature 353, 571–573 (1991). https://doi.org/10.1038/353571a0
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DOI: https://doi.org/10.1038/353571a0
