FANCA facilitates G1/S cell cycle advancement, proliferation, migration and invasion in gastric cancer 

Wei Wang, Shantanu Baral, Bin Liu, Qiannan Sun, Liuhua Wang, Jun Ren, Dong Tang, and Daorong Wang 

Gastric cancer (GC) remains a formidable health challenge worldwide, necessitating ongoing research for better prevention, diagnosis, and treatment strategies. A recent study, conducted by researchers at Northern Jiangsu People’s Hospital and Yangzhou University, sheds new light on the pivotal role of the FANCA gene in GC. The FANCA gene, a crucial player in the Fanconi anemia pathway, is essential for maintaining genomic stability. This study found that elevated FANCA expression in GC cell lines is associated with advanced pathological stages and lymphatic metastasis. Through various cellular assays, the researchers demonstrated that FANCA knockdown inhibits cell proliferation, migration, and invasion, while inducing G1/S phase cell cycle arrest. Conversely, FANCA overexpression enhances these malignant behaviors. These findings, confirmed by in vivo xenograft experiments, highlight FANCA’s potential as a therapeutic target for GC treatment, offering hope for more effective, targeted cancer therapies in the future.

This cover is designed by Yinxi Zhou and Jianfeng Jin from Hainan Medical University.