Abstract
People can respond differently to the same drug used to treat the same condition. Several reasons can account for the range of responses including taking multiple drugs at one time, multiple conditions, race, age, diet, weight, and genetics. This chapter explores how genetics can affect drug response. Knowledge of a patient’s genetic makeup may be used in decisions about drug selection and dosing in order to reduce the risk of side effects and improve the likelihood that a drug will work.
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US National Library of Medicine. Medline Plus—Precision Medicine. Available at https://medlineplus.gov/genetics/understanding/precisionmedicine/
US National Library of Medicine. Medline Plus—What is Pharmacogenomics? Available at https://medlineplus.gov/genetics/understanding/genomicresearch/pharmacogenomics/
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US National Institute for General Medical Sciences. Medicines by Design. Available at https://www.nigms.nih.gov/education/Booklets/medicines-by-design/Pages/Home.aspx
US Centers for Disease Control and Prevention. Pharmacogenomics: What does it mean for your health? Available at https://www.cdc.gov/genomics/disease/pharma.htm
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Haga, S.B. (2022). Will This Drug Work for You?. In: The Book of Genes and Genomes. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70916-1_7
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DOI: https://doi.org/10.1007/978-0-387-70916-1_7
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