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Biosimilars in Clinical Trials
Clinical trials impose validation of safety and efficacy, and biosimilars have contributed large share to the pipeline of clinical trials. These...
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Phases of Clinical Trials
Clinical trials are trials conducted on human subjects. Clinical trials of an investigational drug product (IDP) that are intended to support drug...
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Extracellular Vesicle-Based Clinical Trials
Small extracellular vesicles (sEVs), particularly those derived from stem cells, are considered a new therapeutic alternative for various diseases...
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Randomized Clinical Trials
Observational studies suffer from biases and confounding, which can never be completely eliminated. Whenever feasible and ethically appropriate, a...
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Quality by Design in Relation to Clinical Trials
Clinical trials play a crucial role in evaluating the safety and efficacy of new drugs and treatments. Ensuring the quality and integrity of clinical...
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Clinical Trials and Outcomes in Anti-inflammatory Therapies
Inflammatory diseases represent a diverse group of disorders stemming from an overactive immune response, affecting various organs and tissues and...
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Neurotrophic Factors in Parkinson’s Disease: Clinical Trials
Introduction: Parkinson’s disease (PD)Parkinson’s disease is characterized by the progressive loss of midbrain dopamine (DA) neurons that regulate...
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An Update on Clinical Trials on Synbiotics
Combinations of prebiotics and probiotics are known as “synbiotics,” because certain prebiotic compounds help probiotic bacteria expand. Supplements...
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Clinical Application and Trials with Nutraceuticals
Pharmaceutical drugs are chemical compounds that are designed to prevent, diagnose, and treat a specific disorder. Nutraceuticals are products that...
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Translational Therapeutic Targets: From Bench to Clinical Trials
Globally cancer is a public health concern taking millions of lives worldwide every year. The complex nature of cancer establishment and spread has...
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Clinical therapeutic trials
The term clinical trial implies an investigation of a therapeutic intervention in the pursuit of evidence of benefit, short or sustained, and...
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Ending Clinical Trials Prematurely
Clinical trials can be terminated early for one of three reasons: there is a preponderance of adverse events in one arm, or both arms have more than...
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Digital health technologies and Alzheimer’s disease clinical trials: might decentralized clinical trials increase participation by people with cognitive impairment?
BackgroundTherapeutic trials in Alzheimer’s disease (AD) face many obstacles—particularly with regard to screening and recruitment.
Discussion ...
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Non-inferiority Clinical Trials
Obviously, if we have preliminary evidence that the new treatment has greater efficacy than what is already available, a traditional superiority...
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Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA
Since medicine is, above all, in addition to an art, an experimental science, therapeutic research necessarily implies the carrying out of clinical...
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Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare, adult-onset neurodegenerative movement disorder occurring in some carriers of a 55–200...
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Decentralisation in Clinical Trials and Patient Centricity: Benefits and Challenges
Decentralised clinical trials (DCTs) encompass various terms such as virtual, home-based, remote and siteless trials. The objectives of DCTs are to...
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Review of brachytherapy clinical trials: a cross-sectional analysis of ClinicalTrials.gov
IntroductionCharacterizing the landscape of clinical trials including brachytherapy can provide an overview of the current status and research trends...
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Comparison of clinical outcomes among cancer patients treated in and out of clinical trials
BackgroundIt is unknown if participation in a cancer clinical trial confers clinical benefits to patients. There is not enough scientific evidence in...
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MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies
As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in cancer development. Since the discovery of the identity and...
