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Exploring platelet-derived microvesicles in vascular regeneration: unraveling the intricate mechanisms and molecular mediators
Microvesicles (MVs) serve as biomarkers and transmitters for cell communication and also act as essential contributors to diseases. Platelets release...
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Nano-seq analysis reveals different functional tendency between exosomes and microvesicles derived from hUMSC
BackgroundExtracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUMSCs) are widely considered to be the best mediators for...
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Extracellular microvesicles: biologic properties, biogenesis, and applications in leukemia
Microvesicles are cellular membrane vesicles of which size is limited to 30–1000 nm. Almost all cells release them in response to activation signals...
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Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields
Every single cell can communicate with other cells in a paracrine manner via the production of nano-sized extracellular vesicles. This phenomenon is...
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Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling
BackgroundIschemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have...
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Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke
AimsNeutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during...
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Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues
Extracellular vesicles (EVs) are nanoscale vesicles secreted into the extracellular space by all cell types, including neurons and astrocytes in the...
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Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2
BackgroundOur previous study found that bone marrow-derived mesenchymal stem cells (BMSCs) promote Helicobacter pylori (H pylori) -associated gastric...
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Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics
BackgroundEarly detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor...
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The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis
BackgroundIt is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently...
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Innate Immunity Communicates Using the Language of Extracellular Microvesicles
The innate immunity system and extracellular microvesicles (ExMVs) both emerged early in the evolution of life, which is why its innate immunity...
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Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients
The tumor microenvironment modulates cancer growth. Extracellular vesicles (EVs) have been identified as key mediators of intercellular...
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Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1
Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk...
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Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor
The intraoperative ischemia in partial nephrectomy (PN) often leads to postoperative renal function impairment and fibrosis, which can be regulated...
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Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats
BackgroundSepsis is a major cause of death in ICU, and intestinal barrier dysfunction is its important complication, while the treatment is limited....
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BMSCs-derived Mitochondria Improve Osteoarthritis by Ameliorating Mitochondrial Dysfunction and Promoting Mitochondrial Biogenesis in Chondrocytes
Bone marrow mesenchymal stem cells (BMSCs)—derived exosomes and microvesicles can effectively improve knee osteoarthritis. We found that...
