Experimental models in focal cerebral ischemia: are we there yet?

R R Leker; S Constantini

doi:10.1007/978-3-7091-6743-4_10

Experimental models in focal cerebral ischemia: are we there yet?

Acta Neurochir Suppl. 2002:83:55-9. doi: 10.1007/978-3-7091-6743-4_10.

Authors

R R Leker¹, S Constantini

Affiliation

¹ Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel.

PMID: 12442622
DOI: 10.1007/978-3-7091-6743-4_10

Abstract

Therapeutic options available for acute stroke management are sparse and inadequate. Therefore, new insights into stroke pathophysiology leading to new therapeutic targets are needed. In order to attain these goals, adequate animal models for cerebral ischemia are needed. In the following paper the authors will review the various animal models for stroke and emphasize their potential strengths and weaknesses.

Publication types

Evaluation Study
Review

MeSH terms

Animals
Brain Ischemia / physiopathology*
Brain Ischemia / therapy
Cell Survival / physiology
Cerebral Infarction / physiopathology*
Cerebral Infarction / therapy
Disease Models, Animal*
Humans
Infarction, Anterior Cerebral Artery / physiopathology
Infarction, Anterior Cerebral Artery / therapy
Infarction, Middle Cerebral Artery / physiopathology
Infarction, Middle Cerebral Artery / therapy
Intracranial Embolism / physiopathology
Intracranial Embolism / therapy
Ischemic Attack, Transient / physiopathology
Ischemic Attack, Transient / therapy
Mice
Neurons / physiology
Rats