The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine

Clin J Pain. 2003 May-Jun;19(3):200-1. doi: 10.1097/00002508-200305000-00008.

Abstract

Aim: To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.

Method: A double-blind, placebo-controlled crossover study of 30 adult subjects.

Results: Mean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.

Conclusion: The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Analgesics / administration & dosage
  • Cholecystokinin / antagonists & inhibitors
  • Chronic Disease
  • Codeine / administration & dosage*
  • Codeine / analogs & derivatives*
  • Cross-Over Studies
  • Double-Blind Method
  • Drug Synergism
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain / drug therapy*
  • Placebo Effect
  • Proglumide / administration & dosage*
  • Treatment Outcome

Substances

  • Analgesics
  • Cholecystokinin
  • Proglumide
  • dihydrocodeine
  • Codeine