Abstract
Aim:
To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.
Method:
A double-blind, placebo-controlled crossover study of 30 adult subjects.
Results:
Mean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.
Conclusion:
The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Analgesics / administration & dosage
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Cholecystokinin / antagonists & inhibitors
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Chronic Disease
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Codeine / administration & dosage*
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Codeine / analogs & derivatives*
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Cross-Over Studies
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Double-Blind Method
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Drug Synergism
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Drug Therapy, Combination
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Female
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Humans
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Male
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Middle Aged
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Pain / drug therapy*
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Placebo Effect
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Proglumide / administration & dosage*
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Treatment Outcome
Substances
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Analgesics
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Cholecystokinin
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Proglumide
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dihydrocodeine
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Codeine