A new chiral catalyst for the enantioselective Strecker synthesis of alpha-amino acids

Jinkun Huang; E J Corey

doi:10.1021/ol047698w

A new chiral catalyst for the enantioselective Strecker synthesis of alpha-amino acids

Org Lett. 2004 Dec 23;6(26):5027-9. doi: 10.1021/ol047698w.

Authors

Jinkun Huang¹, E J Corey

Affiliation

¹ Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

PMID: 15606127
DOI: 10.1021/ol047698w

Abstract

[reaction: see text] The chiral ammonium salt 3 is demonstrated to be an effective catalyst for the highly enantioselective Strecker reaction of N-allylbenzaldimines with hydrogen cyanide in CH2Cl2 solution.

MeSH terms

Amino Acids / chemical synthesis*
Amino Acids / chemistry
Catalysis
Molecular Structure
Quaternary Ammonium Compounds / chemistry*
Stereoisomerism

Substances

Amino Acids
Quaternary Ammonium Compounds