Abstract
This review provides a description of the biochemistry and enzymology of the alpha-aminoadipate pathway for lysine biosynthesis in fungi. The alpha-aminoadipate pathway is unique to fungi and is thus a potential target for the rational design of antifungal drugs. The present state of knowledge of the mechanisms of the seven enzymes in the pathway is presented, as well as detailed information with respect to structures and mechanisms of homocitrate synthase, saccharopine reductase, and saccharopine dehydrogenase.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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2-Aminoadipate Transaminase / metabolism
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2-Aminoadipic Acid / metabolism*
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Alcohol Oxidoreductases / metabolism
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Bacteria / metabolism
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Fungi / metabolism*
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Hydro-Lyases / metabolism
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Lysine / biosynthesis*
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Oxo-Acid-Lyases / metabolism
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Plants / metabolism
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Saccharopine Dehydrogenases / metabolism
Substances
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2-Aminoadipic Acid
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Alcohol Oxidoreductases
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homoisocitrate dehydrogenase
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Saccharopine Dehydrogenases
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saccharopine dehydrogenase (NADP, L-glutamate-forming)
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homocitrate synthase
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2-Aminoadipate Transaminase
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Oxo-Acid-Lyases
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Hydro-Lyases
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homoaconitate hydratase
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Lysine