A mariner with crippling arthritis and bleeding eyes

Am J Med Sci. 2006 Sep;332(3):123-30. doi: 10.1097/00000441-200609000-00005.

Abstract

A 41-year-old mariner developed acute arthritis affecting his legs more than his arms or hands during a violent storm on his return from the first of four voyages of discovery. He experienced repeated attacks of the arthritis over the ensuing 14 years, which on at least two occasions were accompanied by painful eyes "much affected with bleeding." He died shortly before his 55 birthday "quite paralyzed and bedridden." Who was he, and what was the likely etiology of his disorder?

Publication types

  • Biography
  • Case Reports
  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Reactive / diagnosis*
  • Arthritis, Reactive / history*
  • Conjunctivitis / diagnosis*
  • Conjunctivitis / history*
  • Diagnosis, Differential
  • Famous Persons*
  • HLA-B27 Antigen / genetics
  • History, 15th Century
  • History, 16th Century
  • Humans
  • Male
  • Middle Aged

Substances

  • HLA-B27 Antigen

Personal name as subject

  • Christopher Columbus