Abstract
The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens / analysis*
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Autoantibodies*
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Autoantigens / analysis*
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Carcinoma, Ehrlich Tumor
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Epitopes
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HeLa Cells
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Humans
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Lupus Erythematosus, Systemic / immunology*
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Nucleoproteins / immunology*
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RNA / immunology
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RNA, Neoplasm / immunology
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RNA, Small Nuclear
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Ribonucleoproteins / immunology*
Substances
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Antigens
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Autoantibodies
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Autoantigens
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Epitopes
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Nucleoproteins
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RNA, Neoplasm
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RNA, Small Nuclear
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Ribonucleoproteins
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RNA