Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

R Freudenthal; F Locatelli; G Hermitte; H Maldonado; C Lafourcade; A Delorenzi; A Romano

doi:10.1016/s0304-3940(98)00059-7

Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus

Neurosci Lett. 1998 Feb 20;242(3):143-6. doi: 10.1016/s0304-3940(98)00059-7.

Authors

R Freudenthal¹, F Locatelli, G Hermitte, H Maldonado, C Lafourcade, A Delorenzi, A Romano

Affiliation

¹ Facultad de Ciencias Exactas y Naturales, Departamento de Ciencias Biológicas, Universidad de Buenos Aires, Argentina.

PMID: 9530926
DOI: 10.1016/s0304-3940(98)00059-7

Abstract

Regulation of gene expression has been involved in long-term memory consolidation. Present results support the role of Rel/ NFkappa-B like activation in this process. In the crab Chasmagnathus, the spaced presentation of 15 or more danger stimuli induces long-term habituation (LTH), while no LTH is observed after a massed training of 600 trials. When a group trained with 30 spaced trials was compared with a passive control group and massed trained groups, a higher level of specific Rel/kappa-B like DNA-binding activity was found in brain nuclear extracts. These results strongly suggest that the enhancement of Rel/kappa-B like DNA-binding activity in the brain is specifically related to LTH formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brachyura / physiology*
Conditioning, Psychological / physiology
Gene Expression Regulation / physiology*
Habituation, Psychophysiologic / genetics*
Male
Memory / physiology*
NF-kappa B / genetics
NF-kappa B / metabolism*
Neuronal Plasticity / genetics
Oligonucleotide Probes
Protein Binding / physiology
Second Messenger Systems / genetics

Substances

NF-kappa B
Oligonucleotide Probes