Objective: To determine if low doses of estrogen and testosterone can improve the semen quality in oligospermic men.
Design: Prospective, nonrandomized, noncontrolled, clinical study.
Setting: Primary level care in private practice.
Patient(s): Fourteen physically healthy and androgenized oligospermic men were selected for the study.
Intervention(s): Combined low-dose estrogen-testosterone was administered orally for 4 months.
Main outcome measure(s): Semen parameters.
Result(s): Nine cases (64.2%) showed definite improvement in the semen quality, five cases (35.8%) did not show much improvement. The wives of three patients (21.4%) became pregnant within 6 months of the initiation of therapy.
Conclusion(s): Low-dose estrogen and testosterone may significantly improve the semen quality in men with oligospermia.