Pharmaceutical polymers and P-glycoprotein: current trends and possible outcomes in drug delivery

MS Attia, MT Elsebaey, G Yahya, H Chopra… - Materials Today …, 2023 - Elsevier
Drug resistance is considered a key reason behind the failure of therapeutic medications in
treating chronic diseases, including hypertension, cancer therapeutics, and antimicrobial …

The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems

L Yin, Y Pang, L Shan, J Gu - Drug Metabolism and Disposition, 2022 - ASPET
Polyethylene glycol (PEG) is one of the most commonly used synthetic macromolecular
polymers for modifying small molecule drugs, peptides, proteins, or nanodrug delivery …

Rediscovery of poly (ethylene glycol) s as a cryoprotectant for mesenchymal stem cells

M Patel, JK Park, B Jeong - Biomaterials Research, 2023 - spj.science.org
Background A medium containing dimethyl sulfoxide (DMSO)(10% v/v) is most widely used
for cell cryopreservation at–196° C. However, residual DMSO consistently raises concerns …

Comparative investigation of cellular effects of polyethylene glycol (PEG) derivatives

H Pham Le Khanh, D Nemes, Á Rusznyák, Z Ujhelyi… - Polymers, 2022 - mdpi.com
Nowadays, polyethylene glycols referred to as PEGs are widely used in cosmetics,
consumer care products, and the pharmaceutical industry. Their advantageous properties …

Ethylene glycol derivative-pendanted quaternary ammonium antibacterial polymers with low cytotoxicity

M Yun, J Lee, SS Shin, SJ Park, J Choi, J Seo… - European Polymer …, 2024 - Elsevier
Cationic poly (quaternary ammonium)(pQA) polymers exhibit excellent antibacterial efficacy
but high cytotoxicity (thus low selectivity), hampering their widespread use as antibacterial …

[HTML][HTML] Biological fate and interaction with cytochromes P450 of the nanocarrier material, d-αあるふぁ-tocopheryl polyethylene glycol 1000 succinate

T Ren, R Li, L Zhao, JP Fawcett, D Sun, J Gu - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract d-αあるふぁ-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-
TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with …

[HTML][HTML] The biological fate of the polymer nanocarrier material monomethoxy poly (ethylene glycol)-block-poly (d, l-lactic acid) in rat

X Meng, Z Zhang, J Tong, H Sun, JP Fawcett… - … Pharmaceutica Sinica B, 2021 - Elsevier
Monomethoxy poly (ethylene glycol)-block-poly (d, l-lactic acid)(PEG-PLA) is a typical
amphiphilic di-block copolymer widely used as a nanoparticle carrier (nanocarrier) in drug …

Optimized Design of Hyaluronic Acid–Lipid Conjugate Biomaterial for Augmenting CD44 Recognition of Surface-Engineered NK Cells

HW Park, W Lee, S Kim, AK Jangid, J Park… - …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) presents treatment challenges due to a lack of
detectable surface receptors. Natural killer (NK) cell-based adaptive immunotherapy is a …

Enhanced cytotoxic activity of pegylated curcumin derivatives: synthesis, structure–activity evaluation, and biological activity

D Lazewski, M Kucinska, E Potapskiy… - International Journal of …, 2023 - mdpi.com
Curcumin has been modified in various ways to broaden its application in medicine and
address its limitations. In this study, we present a series of curcumin-based derivatives …

[HTML][HTML] Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic

A Raza, D Kamato, FB Sime, JA Roberts, A Popat… - Materials Today …, 2022 - Elsevier
Advanced materials-based strategies are proving to be promising in solving the major
problems of oral drug delivery. Herein, Polyethylene glycol (PEG)-functionalized porous …