Simone JCFM Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M De Bont, Yutaka Negishi, Ezio T Fok, Lydia Kalafati, Panayotis Verginis, Vera P Mourits, Valerie ACM Koeken, L Charlotte J De Bree, Ger JM Pruijn, Craig Fenwick, Reinout Van Crevel, Leo AB Joosten, Irma Joosten, Hans Koenen, Musa M Mhlanga, Dimitri A Diavatopoulos, Triantafyllos Chavakis, Mihai G Netea
2020/11/17
Cell reports
33
7
Elsevier
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies have revealed that the induction of trained immunity is associated with a bias toward granulopoiesis in bone marrow hematopoietic progenitor cells, but it is unknown whether BCG vaccination also leads to functional reprogramming of mature neutrophils. Here, we show that BCG vaccination of healthy humans induces long-lasting changes in neutrophil phenotype, characterized by increased expression of activation markers and antimicrobial function. The enhanced function of human neutrophils persists for at least 3 months after vaccination and is associated with genome-wide epigenetic modifications in trimethylation at histone 3 lysine 4. Functional …
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SJ Moorlag, YA Rodriguez-Rosales, J Gillard… - Cell reports, 2020