Natalie A Carter, Rita Vasconcellos, Elizabeth C Rosser, Calogero Tulone, Alba Muñoz-Suano, Masahito Kamanaka, Michael R Ehrenstein, Richard A Flavell, Claudia Mauri
2011/5/15
The Journal of Immunology
186
10
ページ
5569-5579
American Association of Immunologists
IL-10–producing B cells, also known as regulatory B cells (Bregs), play a key role in controlling autoimmunity. In this study, we report that chimeric mice specifically lacking IL-10–producing B cells (IL-10−/− B cell) developed an exacerbated arthritis compared with chimeric wild-type (WT) B cell mice. A significant decrease in the absolute numbers of Foxp3 regulatory T cells (Tregs), in their expression level of Foxp3, and a marked increase in inflammatory Th1 and Th17 cells were detected in IL-10−/− B cell mice compared with WT B cell mice. Reconstitution of arthritic B cell deficient (μ MT) mice with different B cell subsets revealed that the ability to modulate Treg frequencies in vivo is exclusively restricted to transitional 2 marginal zone precursor Bregs. Moreover, transfer of WT transitional 2 marginal zone precursor Bregs to arthritic IL-10−/− mice increased Foxp3+ Tregs and reduced Th1 and Th17 cell frequencies …
Scholar の論文
NA Carter, R Vasconcellos, EC Rosser, C Tulone… - The Journal of Immunology, 2011