Discovery of a potent and selective covalent inhibitor of Bruton's tyrosine kinase with oral anti-inflammatory activity
MS Tichenor, JJM Wiener, NL Rao… - ACS Medicinal …, 2021 - ACS Publications
Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the
activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in …
activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in …
[HTML][HTML] Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity
MS Tichenor, JJM Wiener, NL Rao… - ACS Medicinal …, 2021 - ncbi.nlm.nih.gov
Bruton, s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in
the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types …
the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types …
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity
MS Tichenor, JJM Wiener, NL Rao… - ACS medicinal …, 2021 - pubmed.ncbi.nlm.nih.gov
Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the
activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in …
activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in …
[PDF][PDF] Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity
MS Tichenor, JJM Wiener, NL Rao, CP Deckhut, J Kent… - pstorage-acs-6854636.s3 …
Figure S1. Determination of the atropisomer interconversion barrier for compound 21 S2
Figure S2. Determination of the atropisomer interconversion barrier for compound 23 S3 …
Figure S2. Determination of the atropisomer interconversion barrier for compound 23 S3 …
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
MS Tichenor, JJM Wiener, NL Rao… - ACS Medicinal …, 2021 - europepmc.org
Bruton, s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in
the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types …
the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types …