CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database

BP Alcock, AR Raphenya, TTY Lau… - Nucleic acids …, 2020 - academic.oup.com
Abstract The Comprehensive Antibiotic Resistance Database (CARD; https://card. mcmaster.
ca) is a curated resource providing reference DNA and protein sequences, detection models …

CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database

B Jia, AR Raphenya, B Alcock… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Comprehensive Antibiotic Resistance Database (CARD; http://arpcard.
mcmaster. ca) is a manually curated resource containing high quality reference data on the …

CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

BP Alcock, W Huynh, R Chalil, KW Smith… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Comprehensive Antibiotic Resistance Database (CARD; card. mcmaster. ca)
combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) …

The comprehensive antibiotic resistance database

AG McArthur, N Waglechner, F Nizam… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The field of antibiotic drug discovery and the monitoring of new antibiotic resistance
elements have yet to fully exploit the power of the genome revolution. Despite the fact that …

Mobilization of antibiotic resistance: are current approaches for colocalizing resistomes and mobilomes useful?

IB Slizovskiy, K Mukherjee, CJ Dean… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial resistance (AMR) poses a global human and animal health threat, and
predicting AMR persistence and transmission remains an intractable challenge. Shotgun …

Bioinformatics of antimicrobial resistance in the age of molecular epidemiology

AG McArthur, GD Wright - Current opinion in microbiology, 2015 - Elsevier
Highlights•Examination of antimicrobial resistance is transitioning from phenotype to
genotype.•Whole genome sequencing of pathogens will become a commonplace clinical …

MEGARes 2.0: a database for classification of antimicrobial drug, biocide and metal resistance determinants in metagenomic sequence data

E Doster, SM Lakin, CJ Dean, C Wolfe… - Nucleic acids …, 2020 - academic.oup.com
Antimicrobial resistance (AMR) is a threat to global public health and the identification of
genetic determinants of AMR is a critical component to epidemiological investigations. High …

Capturing the resistome: a targeted capture method to reveal antibiotic resistance determinants in metagenomes

AK Guitor, AR Raphenya, J Klunk, M Kuch… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Identification of the nucleotide sequences encoding antibiotic resistance elements and
determination of their association with antibiotic resistance are critical to improve …

Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

An ISO-certified genomics workflow for identification and surveillance of antimicrobial resistance

NL Sherry, KA Horan, SA Ballard… - Nature …, 2023 - nature.com
Realising the promise of genomics to revolutionise identification and surveillance of
antimicrobial resistance (AMR) has been a long-standing challenge in clinical and public …