In an era of dramatic discoveries in neuroscience and genetics, it is likely that many popular
theories and formulations about mental illness will need to be revised, if not discarded. The …

Background Many studies have shown that structural brain abnormalities in schizophrenia
are already present by the time of index evaluation of first-episode patients. However …

A long-standing view has been that the study of the schizophrenic brain was the graveyard
of neuropathologists. 1 Not too many years ago, inconsistencies in postmortem reports of …

Objective: The author 1) reassesses the case against a neuronal degeneration hypothesis
for schizophrenia; 2) demonstrates that the hypothesis that schizophrenia is a disorder …

The use of structural magnetic resonance imaging (MRI) in studies of schizophrenia has
resulted in a more detailed picture of anatomic areas which may be altered in this syndrome …

Schizophrenia, once considered a psychological malady devoid of any organic brain
substrate, has been the focus of intense neuroimaging research. Findings reveal mild but …

Brain morphology was examined using magnetic resonance imaging in 30 first-episode
patients with a schizophreniclike psychosis, 15 chronic schizophenics, and 20 neurological …

Defining the lifetime trajectory of schizophrenia and the mechanisms that drive it is one of
the major challenges of schizophrenia research. Kraepelin assumed that the mechanisms …

Brain morphological abnormalities have been reported in several independent
investigations of chronic schizophrenic patients. The present study is a prospective 4-year …

• We used magnetic resonance imaging to examine the morphologic characteristics of the
amygdala/hippocampus, prefrontal cortex, and caudate nucleus in 29 healthy volunteers …