Background An outbreak of tuberculosis occurred over a 3-year period in a medium-size
community in British Columbia, Canada. The results of mycobacterial interspersed repetitive …

Background Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to
guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient …

Background Tuberculosis incidence in the UK has risen in the past decade. Disease control
depends on epidemiological data, which can be difficult to obtain. Whole-genome …

Rationale Current tools available to study the molecular epidemiology of tuberculosis do not
provide information about the directionality and sequence of transmission for tuberculosis …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been used to trace
the transmission of M. tuberculosis, the causative agent of tuberculosis (TB). Previously …

Background. Whole-genome sequencing (WGS) is increasingly used in molecular-
epidemiological investigations of bacterial pathogens, despite cost-and time-intensive …

Background Recurrence of tuberculosis after treatment makes management difficult and is a
key factor for determining treatment efficacy. Two processes can cause recurrence: relapse …

Abstract Background Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem
Repeat (MIRU-VNTR) typing is widely used in high-income countries to determine …

To improve understanding of the factors influencing tuberculosis transmission and the role of
pathogen variation, we sequenced all available specimens from patients diagnosed over 15 …

Standardized mycobacterial interspersed repetitive-unit-variable-number tandem repeat
(MIRU-VNTR) typing based on 15 and 24 loci recently has been proposed for …