Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Lamins are inner nuclear membrane proteins that belong to the intermediate filament family.
Lamin A/C lie adjacent to the heterochromatin structure in polymer form, providing skeletal to …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …

Network embedding approaches are gaining momentum to analyse a large variety of
networks. Indeed, these approaches have demonstrated their effectiveness in tasks such as …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …

While more than 7000 rare diseases have been identified, only about 5 percent benefit from
a licensed treatment. As the majority of these diseases is life threatening, these facts …

Abstract Purpose of Review This review provides an overview of genetic and non-genetic
causes of premature coronary artery disease (pCAD). Recent Findings pCAD refers to …

Collectively, genetic disorders affect approximately 350 million individuals worldwide and
are a major global health burden. Despite substantial progress in identification of new …