Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches

S Heymans, NK Lakdawala, C Tschöpe, K Klingel - The Lancet, 2023 - thelancet.com
Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …

Arrhythmias as presentation of genetic cardiomyopathy

J Lukas Laws, MC Lancaster… - Circulation …, 2022 - Am Heart Assoc
There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary

EC Storey, HR Fuller - Cells, 2022 - mdpi.com
Mutations in genes encoding proteins associated with the linker of nucleoskeleton and
cytoskeleton (LINC) complex within the nuclear envelope cause different diseases with …

Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure …

RA de Boer, S Heymans, J Backs… - European journal of …, 2022 - Wiley Online Library
Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …

Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know

U Tayal, JS Ware, NK Lakdawala… - European Heart …, 2021 - academic.oup.com
There is increasing understanding of the genetic basis to dilated cardiomyopathy and in this
review, we offer a practical primer for the practising clinician. We aim to help all clinicians …

Atrial cardiomyopathy: from cell to bedside

M Li, Y Ning, G Tse, AM Saguner, M Wei… - ESC heart …, 2022 - Wiley Online Library
Atrial cardiomyopathy refers to structural and electrical remodelling of the atria, which can
lead to impaired mechanical function. While historical studies have implicated atrial …

Genetic background and clinical features in arrhythmogenic left ventricular cardiomyopathy: a systematic review

R Bariani, I Rigato, M Cason, M Bueno Marinas… - Journal of Clinical …, 2022 - mdpi.com
In recent years a phenotypic variant of Arrhythmogenic cardiomyopathy has been described,
characterized by predominant left ventricular (LV) involvement with no or minor right …

REALM-DCM: A Phase 3, Multinational, Randomized, Placebo-Controlled Trial of ARRY-371797 in Patients With Symptomatic LMNA-Related Dilated …

P Garcia-Pavia, JFR Palomares, G Sinagra… - Circulation: Heart …, 2024 - ahajournals.org
BACKGROUND: LMNA (lamin A/C)-related dilated cardiomyopathy is a rare genetic cause
of heart failure. In a phase 2 trial and long-term extension, the selective p38αあるふぁ MAPK …

Hypertrophic, dilated, and arrhythmogenic cardiomyopathy: where are we?

H El Hadi, A Freund, S Desch, H Thiele, N Majunke - Biomedicines, 2023 - mdpi.com
Cardiomyopathies are a heterogeneous group of structural, mechanical, and electrical heart
muscle disorders which often correlate with life-threatening arrhythmias and progressive …

Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations

J Yang, MA Argenziano, M Burgos Angulo… - Frontiers in …, 2021 - frontiersin.org
Mutations in the LMNA gene (encoding lamin A/C) are a significant cause of familial
arrhythmogenic cardiomyopathy. Although the penetrance is high, there is considerable …