The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …

CRISPR-Cas9 gene editing is emerging as a prospective therapy for genomic mutations.
However, current editing approaches are directed primarily toward relatively small cohorts of …

Dilated cardiomyopathy is the second most common cause for heart failure with no cure
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …

Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's
disease represent some of the most prevalent neurodegenerative disorders afflicting …

Cardiomyopathies are among the major triggers of heart failure, but their clinical and genetic
complexity have hampered our understanding of these disorders and delayed the …

Cardiovascular diseases are the most common cause of worldwide morbidity and mortality,
highlighting the necessity for advanced therapeutic strategies. Ca2+/calmodulin-dependent …

Superhydrophilic surfaces play an important role in nature. Inspired by this, scientists have
designed various superhydrophilic materials that are widely used in the field of biomaterials …

This article reviews progress in the field of cardiac genome editing, in particular, its potential
utility in treating cardiac arrhythmias. First, we discuss genome editing methods by which …