Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

A review of neutrophil extracellular traps (NETs) in disease: potential anti-NETs therapeutics

V Mutua, LJ Gershwin - Clinical reviews in allergy & immunology, 2021 - Springer
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of
stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Natural killer cell dysfunction and its role in COVID-19

C van Eeden, L Khan, MS Osman… - International journal of …, 2020 - mdpi.com
When facing an acute viral infection, our immune systems need to function with finite
precision to enable the elimination of the pathogen, whilst protecting our bodies from …

Role of gut microbiota in infectious and inflammatory diseases

MF Maciel-Fiuza, GC Muller, DMS Campos… - Frontiers in …, 2023 - frontiersin.org
Thousands of microorganisms compose the human gut microbiota, fighting pathogens in
infectious diseases and inhibiting or inducing inflammation in different immunological …

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

H Dejima, X Hu, R Chen, J Zhang, J Fujimoto… - Nature …, 2021 - nature.com
The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung
adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of …

The role of inflammation in autoimmune disease: a therapeutic target

Y Xiang, M Zhang, D Jiang, Q Su, J Shi - Frontiers in Immunology, 2023 - frontiersin.org
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

Telitacicept: first approval

S Dhillon - Drugs, 2021 - Springer
Telitacicept (Tai'ai®) is fusion protein comprising a recombinant transmembrane activator
and calcium modulator and cyclophilin ligand interactor (TACI) receptor fused to the …

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

F Lv, Y He, H Xu, Y Li, L Han, L Yan, H Lang… - Cell death & …, 2022 - nature.com
A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining
potential therapeutic targets to prevent podocyte injury is important from a clinical …

Involvement of trained immunity during autoimmune responses

VP Mora, RA Loaiza, JA Soto, K Bohmwald… - Journal of …, 2023 - Elsevier
Recently, it has been described that innate immune cells such as monocytes, macrophages,
and natural killer cells can develop a non-specific immune response induced by different …