Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and
laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Background The dynamic 3D organization of the genome is central to gene regulation and
development. The nuclear lamina influences genome organization through the tethering of …

Cell migration occurs in confined microenvironments, which plays a vital role in the process
of tumor metastasis. However, it is challenging to study their behaviors in vivo. Here we …

Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

A-type lamins are the main structural components of the nucleus, which are mainly localized
at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins …