In eukaryotic cells, the genome is organized in the form of chromatin composed of DNA and
histones that organize and regulate gene expression. The dysregulation of chromatin …

Nuclear lamins are ancient type V intermediate filaments with diverse functions that include
maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin …

Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear
periphery. These domains have been implicated in gene repression, especially in the …

Mechanical stimuli from the extracellular environment affect cell morphology and
functionality. Recently, we reported that mesenchymal stem cells (MSCs) grown in a custom …

Induction of cellular senescence or cancer is associated with a reshaping of the nuclear
envelope and a broad reorganization of heterochromatin. At the periphery of mammalian …

Cancer development and progression are demarcated by transcriptional dysregulation,
which is largely attributed to aberrant chromatin architecture. Recent transformative …

The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …

Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the
genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is …

Mutations and defects in nuclear lamins can cause major pathologies, including
inflammation and inflammatory diseases. Yet, the underlying molecular mechanisms are not …

The nucleus is a highly organized membrane-bound organelle that envelops and regulates
multiple aspects of the genome. The nuclear membrane is composed of a complex lipid …