Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope
D Zhao, X Gao, J Zhou, J Li, Y Qian, D Wang, W Niu… - BMC biology, 2023 - Springer
Background Nme2ABE8e has been constructed and characterized as a compact, accurate
adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM …
adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM …
[HTML][HTML] Navigating Lipodystrophy: Insights from Laminopathies and Beyond
P Krüger, R Hartinger, K Djabali - International Journal of Molecular …, 2024 - mdpi.com
Recent research into laminopathic lipodystrophies—rare genetic disorders caused by
mutations in the LMNA gene—has greatly expanded our knowledge of their complex …
mutations in the LMNA gene—has greatly expanded our knowledge of their complex …
[HTML][HTML] Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model
Varicella zoster virus (VZV) is the etiological agent of shingles, a painful skin rash that affects
a significant proportion of the elderly population. In the present study, we used two aging cell …
a significant proportion of the elderly population. In the present study, we used two aging cell …
Hutchinson-Gilford progeria syndrome complicated with stroke: A report of 2 cases and literature review
J Wang, Q Yu, X Ma, Z Yuan, J Mao - Frontiers in Pediatrics, 2022 - frontiersin.org
Background Hutchinson–Gilford Progeria Syndrome (HGPS) is a ultrarare, fatal autosomal
dominant disorder. The pathogenesis of the disease is a mutation in LMNA, which leads to …
dominant disorder. The pathogenesis of the disease is a mutation in LMNA, which leads to …
Seeking a cure for one of the rarest diseases: progeria
FS Collins - Circulation, 2016 - Am Heart Assoc
127 was originally developed for the treatment of cancer. In 2012, researchers reported that
children with HGPS receiving lonafarnib showed modest improvement in weight gain and a …
children with HGPS receiving lonafarnib showed modest improvement in weight gain and a …
Craniofacial abnormalities in Hutchinson-Gilford progeria syndrome
NJ Ullrich, VM Silvera, SE Campbell… - American journal of …, 2012 - Am Soc Neuroradiology
HGPS is a rare syndrome of segmental premature aging. Our goal was to expand the scope
of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR …
of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR …
Metabolic Bone Diseases Affecting Tooth Eruption: A Narrative Review
CI Papadopoulou, I Sifakakis, S Tournis - Children, 2024 - mdpi.com
Tooth eruption is an essential process for the development of the oral and maxillofacial
system. Several inherited and acquired diseases might affect this tightly regulated process …
system. Several inherited and acquired diseases might affect this tightly regulated process …
How research on human progeroid and antigeroid syndromes can contribute to the longevity dividend initiative
FM Hisama, J Oshima… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Although translational applications derived from research on basic mechanisms of aging are
likely to enhance health spans and life spans for most of us (the longevity dividend), there …
likely to enhance health spans and life spans for most of us (the longevity dividend), there …
Review of how genetic research on segmental progeroid syndromes has documented genomic instability as a hallmark of aging but let us now Pursue Antigeroid …
The purpose of this early contribution to the new Fellows Forum of this pioneering journal for
what is now called Geroscience is to provide an example of how the author's interest in …
what is now called Geroscience is to provide an example of how the author's interest in …
Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome
LB Gordon, S Basso, J Maestranzi, E Aikawa… - Frontiers in …, 2024 - frontiersin.org
Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging
disease that is historically fatal in teenage years, secondary to severe accelerated …
disease that is historically fatal in teenage years, secondary to severe accelerated …