Background Nme2ABE8e has been constructed and characterized as a compact, accurate
adenine base editor with a less restrictive dinucleotide protospacer-adjacent motif (PAM …

Recent research into laminopathic lipodystrophies—rare genetic disorders caused by
mutations in the LMNA gene—has greatly expanded our knowledge of their complex …

Varicella zoster virus (VZV) is the etiological agent of shingles, a painful skin rash that affects
a significant proportion of the elderly population. In the present study, we used two aging cell …

Background Hutchinson–Gilford Progeria Syndrome (HGPS) is a ultrarare, fatal autosomal
dominant disorder. The pathogenesis of the disease is a mutation in LMNA, which leads to …

127 was originally developed for the treatment of cancer. In 2012, researchers reported that
children with HGPS receiving lonafarnib showed modest improvement in weight gain and a …

HGPS is a rare syndrome of segmental premature aging. Our goal was to expand the scope
of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR …

Tooth eruption is an essential process for the development of the oral and maxillofacial
system. Several inherited and acquired diseases might affect this tightly regulated process …

Although translational applications derived from research on basic mechanisms of aging are
likely to enhance health spans and life spans for most of us (the longevity dividend), there …

The purpose of this early contribution to the new Fellows Forum of this pioneering journal for
what is now called Geroscience is to provide an example of how the author's interest in …

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging
disease that is historically fatal in teenage years, secondary to severe accelerated …