Oxidative stress (OS) is one of the most frequently recognized causes of ageing. Telomere
erosion, defects in the DNA damage response and alterations in the nuclear architecture are …

Purpose To establish the natural history of ophthalmic characteristics in Progeria patients
and to determine incidence of ocular manifestations. Design Retrospective case series of …

Hutchinson–Gilford progeria syndrome is an extremely rare genetic disease caused by a de
novo mutation in the LMNA gene, leading to an accumulation of a form of Lamin A, called …

Progeria is an ultra-rare (prevalence 1 in 20 million), fatal, pediatric autosomal dominant
premature aging disease caused by a mutation in the LMNA gene. This mutation results in …

Hutchinson–Gilford progeria syndrome (HGPS) is a detrimental premature aging disease
caused by a point mutation in the human LMNA gene. This mutation results in the abnormal …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by
Hutchinson in 1886. Death result from cardiac complications in the majority of cases and …

A single dose of an adenine base editor shows promise in treating the ageing-related
disease Hutchinson–Gilford progeria syndrome. It corrected the LMNA mutation underlying …

Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric
segmental premature aging disease. Cardiovascular and cerebrovascular diseases …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare dysmorphic syndrome characterized
by several features of premature aging with clinical involvement of the skin, bones, and …

Wiedemann–Rautenstrauch syndrome (WRS) is a rare autosomal recessive disorder that
includes premature aging phenotype at birth. The condition is also known as a neonatal …