Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric
segmental premature aging disease. Cardiovascular and cerebrovascular diseases …

Hutchinson-Gilford progeria (HGPS) is a rare, genetic progeroid disorder that causes
premature ageing, nuclear lamina shape abnormalities, growth impairment, and early death …

Progeroid syndromes are diseases that display old-age features such as skin aging (loss of
elastin and skin thinning), cardiovascular problems, alopecia at young ages. One of the most …

B. Other diagnoses/indications 1. Refer to the off-label use policy for the relevant line of
business if diagnosis is NOT specifically listed under section III (Diagnoses/Indications for …

This thesis describes a novel stem cell isolation method using a specific type of stress on pre-
established fibroblasts. As a result, skin-derived precursor cells were successfully isolated …

Abstract The Hutchinson-Gilford Progeria syndrome (HGPS) is a rare genetic disease that
causes an early accelerated aging in children; clinically characterized by manifestations …

INTRODUCTION—The LMNA gene on chromosome 1q encodes prelamin A. Prelamin A is
ultimately converted to lamin A, a critically important structural protein component of the …

Abstract 'Nuclear mechanosensing'encompasses a wide range of biophysical pathways that
are emerging as key processes in the regulation of cell function and fate. Many of these …

Various proteins compose the connective tissue that is found in normal skin and account for
its strength and elasticity. Abnormalities in the structure or function of any of these essential …

Background: Progeroid syndromes are a group or rare genetic disorders that mimic
physiological aging. Some of the syndromes in this group are presented at birth and …