Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of
adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired …

Lungs undergo mechanical strain during breathing, but how these biophysical forces affect
cell fate and tissue homeostasis are unclear. We show that biophysical forces through …

Background Association of chromatin with lamin proteins at the nuclear periphery has
emerged as a potential mechanism to coordinate cell type-specific gene expression and …

The human genome functions as a three-dimensional chromatin polymer, driven by a
complex collection of chromosome interactions,–. Although the molecular rules governing …

Tight control of cell fate choices is crucial for normal development. Here we show that lamin
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Intermediate filaments are major components of the cytoskeleton. Desmin and synemin,
cytoplasmic intermediate filament proteins and A-type lamins, nuclear intermediate filament …

Mutations in the LMNA gene encoding Lamin A and C (Lamin A/C), major components of the
nuclear lamina, cause laminopathies including dilated cardiomyopathy (DCM), but the …

A-type lamins are the main structural components of the nucleus, which are mainly localized
at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins …