Sirtuin 1 and skin: implications in intrinsic and extrinsic aging—a systematic review
A Bielach-Bazyluk, E Zbroch, H Mysliwiec… - Cells, 2021 - mdpi.com
Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …
Sirtuins in dermatology: applications for future research and therapeutics
Sirtuins are a family of seven proteins in humans (SIRT1–SIRT7) that are involved in
multiple cellular processes relevant to dermatology. The role of sirtuins in other organ …
multiple cellular processes relevant to dermatology. The role of sirtuins in other organ …
Sirtuins in skin and skin cancers
LM Garcia-Peterson, MJ Wilking-Busch… - Skin Pharmacology and …, 2017 - karger.com
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These
NAD+-dependent proteins have been found to be intricately involved in a variety of …
NAD+-dependent proteins have been found to be intricately involved in a variety of …
[PDF][PDF] Innovative cosmeceuticals: sirtuin activators and anti-glycation compounds
PK Farris - Seminars in cutaneous medicine and surgery, 2011 - cdn.mdedge.com
Skin aging is a combination of natural aging with superimposed photoaging. Naturally aged
skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with …
skin is thin, fragile and finely wrinkled whereas photoaged skin is rough and thickened with …
Understanding the potential role of sirtuin 2 on aging: consequences of SIRT2. 3 overexpression in senescence
N Sola-Sevilla, A Ricobaraza… - International Journal of …, 2021 - mdpi.com
Sirtuin 2 (SIRT2) has been associated to aging and age-related pathologies. Specifically, an
age-dependent accumulation of isoform 3 of SIRT2 in the CNS has been demonstrated; …
age-dependent accumulation of isoform 3 of SIRT2 in the CNS has been demonstrated; …
Seven sirtuins for seven deadly diseases ofaging
BJ Morris - Free Radical Biology and Medicine, 2013 - Elsevier
Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …
extensive review describes the numerous intracellular actions of the seven mammalian …
The sirtuin family's role in aging and age-associated pathologies
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
invoked by cells to aid in the defense against a vast array of stressors. The pathologies …
[HTML][HTML] Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1
A Martínez-Gutiérrez, I Fernández-Duran… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
UV radiation is one of the main contributors to skin photoaging by promoting the
accumulation of cellular senescence, which in turn induces a proinflammatory and tissue …
accumulation of cellular senescence, which in turn induces a proinflammatory and tissue …
Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
Stresses, such as exposure to ultraviolet radiation and those associated with aging, are
known to cause premature cellular senescence that is characterized by growth arrest and …
known to cause premature cellular senescence that is characterized by growth arrest and …
[HTML][HTML] Pro-proliferative function of mitochondrial sirtuin deacetylase SIRT3 in human melanoma
Melanoma, the most aggressive form of skin cancer, is often fatal if not treated early.
Therefore, novel target-based strategies are required to combat this neoplasm. The …
Therefore, novel target-based strategies are required to combat this neoplasm. The …