LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the
nuclear periphery. Mutations in LMNA cause degenerative disorders including the …

Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by a
point mutation on the LMNA gene. We reported previously that the accumulation of the …

Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near …

Mutations in the A-type lamins A and C, two major components of the nuclear lamina, cause
a large group of phenotypically diverse diseases collectively referred to as laminopathies …

The discoveries of at least eight human diseases arising from mutations in LMNA, which
encodes the nuclear A-type lamins, have revealed the nuclear envelope as an organelle …

Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging
disease, progeria. Some of these are located in the αあるふぁ-helical central rod domain required for …

Lamina-associated polypeptide 2αあるふぁ (LAP2αあるふぁ) localizes throughout the nucleoplasm and
interacts with the fraction of lamins A/C that is not associated with the peripheral nuclear …

The nuclear lamina is a network of structural filaments, the A and B type lamins, located at
the nuclear envelope and throughout the nucleus. Lamin filaments provide the nucleus with …

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents
of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein …

Mutations in the gene encoding nuclear lamin A (LA) cause the premature aging disease
Hutchinson–Gilford Progeria Syndrome. The most common of these mutations results in the …