Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Lamina-associated domains (LADs) are large genomic regions that interact with the nuclear
lamina (NL) and help to guide the spatial folding of chromosomes in the interphase nucleus …

The nuclear lamina is a proteinaceous network of filaments that provide both structural and
gene regulatory functions by tethering proteins and large domains of DNA, the so-called …

The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear
membrane, thereby providing a platform for chromatin binding and supporting genome …

Transcriptionally inactive genes are often positioned at the nuclear lamina (NL), as part of
large lamina‐associated domains (LADs). Activation of such genes is often accompanied by …

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina
associated domains (LADs). The dynamics of these interactions and the relation to …

It is largely unclear whether genes that are naturally embedded in lamina-associated
domains (LADs) are inactive due to their chromatin environment or whether LADs are …

In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …

Abstract Background Lamina-associated domains (LADs) are large genomic regions that
are positioned at the nuclear lamina. It has remained largely unclear what drives the …