Virtually all cell types have the same DNA, yet each type exhibits its own cell-specific pattern
of gene expression. During the brief period of mitosis, the chromosomes exhibit changes in …

Mitosis is accompanied by dramatic changes in chromatin organization and nuclear
architecture. Transcription halts globally and most sequence-specific transcription factors …

The highly reproducible inheritance of chromosomes during mitosis in mammalian cells
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …

During development, discrete cell fates are established in precise spatiotemporal order
guided by morphogen signals. These signals converge in the nucleus to induce …

Transcription represents a central aspect of gene expression with RNA polymerase
machineries (RNA Pol) driving the synthesis of RNA from DNA template molecules. In …

When cells enter mitosis, they undergo series of dramatic changes in their structure and
function that severely hamper gene regulatory processes and gene transcription. This raises …

The regulatory information for phenotype, proliferation, and growth of normal and tumor cells
must be maintained through genome replication in the S phase and cell division during …

Mitosis entails global alterations to chromosome structure and nuclear architecture,
concomitant with transient silencing of transcription. How cells transmit transcriptional states …

Since the earliest observations of cells undergoing mitosis, it has been clear that there is an
intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear …

Mitotic bookmarking transcription factors (BFs) maintain the capacity to bind to their targets
during mitosis, despite major rearrangements of the chromatin. While they were thought to …