A comprehensive review of calcium electroporation—A novel cancer treatment modality

SK Frandsen, M Vissing, J Gehl - Cancers, 2020 - mdpi.com
Calcium electroporation is a potential novel anti-cancer treatment where high calcium
concentrations are introduced into cells by electroporation, a method where short, high …

A review on differences in effects on normal and malignant cells and tissues to electroporation-based therapies: A focus on calcium electroporation

SK Frandsen, J Gehl - Technology in cancer research & …, 2018 - journals.sagepub.com
Calcium electroporation is a potential novel anticancer treatment, where high concentrations
of calcium are introduced into the cell cytosol by electroporation. This is a method where …

Normal and malignant cells exhibit differential responses to calcium electroporation

SK Frandsen, MB Krüger, UM Mangalanathan… - Cancer research, 2017 - AACR
Calcium electroporation may offer a simple general tool for anticancer therapy. Transient
permeabilization of cancer cell membranes created by applying short, high-voltage pulses in …

[HTML][HTML] Calcium electroporation for treatment of sarcoma in preclinical studies

A Szewczyk, J Gehl, M Daczewska, J Saczko… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Calcium electroporation (CaEP) describes the use of electric pulses (electroporation) to
transiently permeabilize cells to allow supraphysiological doses of calcium to enter the …

Calcium electroporation: evidence for differential effects in normal and malignant cell lines, evaluated in a 3D spheroid model

SK Frandsen, L Gibot, M Madi, J Gehl, MP Rols - PLoS One, 2015 - journals.plos.org
Background Calcium electroporation describes the use of high voltage electric pulses to
introduce supraphysiological calcium concentrations into cells. This promising method is …

Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis

SK Frandsen, H Gissel, P Hojman, T Tramm, J Eriksen… - Cancer research, 2012 - AACR
Electroporation of cells with short, high-voltage pulses causes a transient permeabilization
of cell membranes that permits passage of otherwise nonpermeating ions and molecules. In …

Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with …

H Falk, LW Matthiessen, G Wooler, J Gehl - Acta Oncologica, 2018 - Taylor & Francis
Background: Calcium electroporation is a novel anticancer treatment, which utilizes high
voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological …

Dose-dependent ATP depletion and cancer cell death following calcium electroporation, relative effect of calcium concentration and electric field strength

EL Hansen, EB Sozer, S Romeo, SK Frandsen… - PLoS …, 2015 - journals.plos.org
Background Electroporation, a method for increasing the permeability of membranes to ions
and small molecules, is used in the clinic with chemotherapeutic drugs for cancer treatment …

Calcium electroporation induces tumor eradication, long-lasting immunity and cytokine responses in the CT26 colon cancer mouse model

H Falk, PF Forde, ML Bay, UM Mangalanathan… - …, 2017 - Taylor & Francis
Electroporation is used in cancer treatment because of its ability to increase local cytotoxicity
of eg bleomycin (electrochemotherapy) and calcium (calcium electroporation). Calcium …

Effect of calcium electroporation on tumour vasculature

B Staresinic, T Jesenko, U Kamensek… - Scientific reports, 2018 - nature.com
Calcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by
internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has …