Cytoskeletal disruption after electroporation and its significance to pulsed electric field therapies

PM Graybill, RV Davalos - Cancers, 2020 - mdpi.com
Pulsed electric fields (PEFs) have become clinically important through the success of
Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs …

Pulsed electric fields in oncology: A snapshot of current clinical practices and research directions from the 4th world congress of electroporation

LG Campana, A Daud, F Lancellotti, JP Arroyo… - Cancers, 2023 - mdpi.com
Simple Summary Locoregional therapies play an ever-increasing role in contemporary
oncology. This review provides an up-to-date, informed analysis of locoregional therapies …

High-voltage electrical pulses in oncology: irreversible electroporation, electrochemotherapy, gene electrotransfer, electrofusion, and electroimmunotherapy

B Geboers, HJ Scheffer, PM Graybill, AH Ruarus… - Radiology, 2020 - pubs.rsna.org
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

Enhancing irreversible electroporation by manipulating cellular biophysics with a molecular adjuvant

JW Ivey, EL Latouche, ML Richards, GJ Lesser… - Biophysical journal, 2017 - cell.com
Pulsed electric fields applied to cells have been used as an invaluable research tool to
enhance delivery of genes or other intracellular cargo, as well as for tumor treatment via …

A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue

PA Garcia, RV Davalos, D Miklavcic - PloS one, 2014 - journals.plos.org
Electroporation-based therapies are powerful biotechnological tools for enhancing the
delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs) …

Diverse effects of nanosecond pulsed electric fields on cells and tissues

SJ Beebe, J White, PF Blackmore, Y Deng… - DNA and cell …, 2003 - liebertpub.com
The application of pulsed electric fields to cells is extended to include nonthermal pulses
with shorter durations (10-300 ns), higher electric fields (≤ 350 kV/cm), higher power …

[HTML][HTML] Cell death due to electroporation–a review

TB Napotnik, T Polajžer, D Miklavčič - Bioelectrochemistry, 2021 - Elsevier
Exposure of cells to high voltage electric pulses increases transiently membrane
permeability through membrane electroporation. Electroporation can be reversible and is …

Nanosecond pulsed electric fields have differential effects on cells in the S-phase

EH Hall, KH Schoenbach, SJ Beebe - DNA and Cell Biology, 2007 - liebertpub.com
Nanosecond pulsed electric fields (nsPEFs) are a type of nonthermal, nonionizing radiation
that exhibit intense electric fields with high power, but low energy. NsPEFs extend …

Experimental studies on killing and inhibiting effects of steep pulsed electric field (SPEF) to target cancer cell and solid tumor

C Yao, C Sun, Y Mi, L Xiong… - IEEE Transactions on …, 2004 - ieeexplore.ieee.org
Electroporation (ie, reversible electrical breakdown) has been used for biomedicine such as
electroporation therapy, transdermal drug delivery, cellular drug carrier systems, and gene …

The endothelial cytoskeleton as a target of electroporation-based therapies

C Kanthou, S Kranjc, G Sersa, G Tozer, A Zupanic… - Molecular cancer …, 2006 - AACR
Electroporation-based therapies, such as electrochemotherapy and electrogene therapy,
result in the disruption of blood vessel networks in vivo and cause changes in blood flow …