Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

B Rehermann - Nature medicine, 2013 - nature.com
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

[HTML][HTML] Innate and adaptive immune responses in HCV infections

MH Heim, R Thimme - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus has been identified a quarter of a decade ago as a leading cause of
chronic viral hepatitis that can lead to cirrhosis and hepatocellular carcinoma. Only a …

Control of human viral infections by natural killer cells

S Jost, M Altfeld - Annual review of immunology, 2013 - annualreviews.org
Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …

Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human immunodeficiency …

NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

Organ-specific features of natural killer cells

FD Shi, HG Ljunggren, A La Cava… - Nature Reviews …, 2011 - nature.com
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function

E Serti, X Chepa-Lotrea, YJ Kim, M Keane, N Fryzek… - Gastroenterology, 2015 - Elsevier
Background & Aims Chronic hepatitis C virus infection activates an intrahepatic immune
response, leading to increased expression of interferon (IFN)-stimulated genes and …

Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections

B Oliviero, S Varchetta, E Paudice, G Michelone… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The phenotypic and functional characteristics of natural killer (NK)
cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are …

Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function

E Montaldo, GD Zotto, MD Chiesa, MC Mingari… - Cytometry Part …, 2013 - Wiley Online Library
Natural killer (NK) cells are important components of the innate immunity and play a key role
in host defense by virtue of their ability to release cytokines and to mediate cytolytic activity …

Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

B Gao, S Radaeva, O Park - Journal of leukocyte biology, 2009 - academic.oup.com
Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …