In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1
to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism
that culminates with the lysosomal degradation of superfluous or potentially dangerous …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with limited understanding of its pathogenesis and a lack of effective …

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …

Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Beyond the consolidated role in degrading and recycling cellular waste, the autophagic-and
endo-lysosomal systems play a crucial role in extracellular release pathways. Lysosomal …