MicroRNAs (miRNAs) are a class of non‐coding single‐stranded RNA molecules with a
length of approximately 18‐25 nt nucleotides that regulate gene expression post …

Common models used in breast cancer studies, including two-dimensional (2D) cultures
and animal models, do not precisely model all aspects of breast tumors. These models do …

Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor
heterogeneity is associated with metastasis, relapse, and therapy resistance. These factors …

An accumulation of previous work has established organoids as good preclinical models of
human tumors, facilitating translation from basic research to clinical practice. They are …

Embryonic genetic programs are reactivated in response to various types of tissue damage,
providing cell plasticity for tissue regeneration or disease progression. In acute conditions …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Pancreas development is tightly controlled by multilayer mechanisms. Despite years of
effort, large gaps remain in understanding how histone modifications coordinate pancreas …

Simple Summary Acquired resistance of cancer cells to targeted therapy poses a major
clinical problem. Hyperactivation of the PI3K/Akt pathway is common in human …

Background: Breast cancer is the most common type of invasive cancer in women in their
forties and fifties. Recent evidence suggests that JAK2/STAT3 signaling is constitutively …

Background: Breast cancer is the most common type of invasive cancer in women in their
forties and fifties. Recent evidence suggests that JAK2/STAT3 signaling is constitutively …