Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

Patients with acutely decompensated cirrhosis have a dismal prognosis and frequently
progress to acute-on-chronic liver failure, which is characterised by hepatic and extrahepatic …

Cellular crosstalk is a process through which a message is transmitted within an individual
cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular …

The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

Liver fibrosis is defined as excessive extracellular matrix deposition and is based on
complex interactions between matrix-producing hepatic stellate cells and an abundance of …

Chronic liver disease is associated with remarkable alterations in the intra-and extrahepatic
vasculature. Because of these changes, the fields of liver vasculature and portal …

Background & Aims The combination of βべーた-blockers and band ligation is the standard
approach to prevent variceal rebleeding, but bleeding recurs and mortality is high. The lipid …