AMPK at the nexus of energetics and aging
When energy supply is low, organisms respond by slowing aging and increasing resistance
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
Z Sun, Q Jiang, J Li, J Guo - Signal transduction and targeted therapy, 2020 - nature.com
Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …
functions mainly involve in regulating energy response-related physiological processes …
Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced …
Increasing evidence points to the effect of the gut microbiota on central nervous system
functions. Supplementation of certain microbial strains has been demonstrated to alleviate …
functions. Supplementation of certain microbial strains has been demonstrated to alleviate …
The salt-inducible kinases: emerging metabolic regulators
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein
kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for …
kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for …
The multiple roles of salt-inducible kinases in regulating physiology
A Jagannath, L Taylor, Y Ru, Z Wakaf… - Physiological …, 2023 - journals.physiology.org
Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …
kinases, were first described for their role in sodium sensing but have since been shown to …
Emerging roles of CREB-regulated transcription coactivators in brain physiology and pathology
CA Saura, JR Cardinaux - Trends in neurosciences, 2017 - cell.com
The brain has the ability to sense, coordinate, and respond to environmental changes
through biological processes involving activity-dependent gene expression. cAMP-response …
through biological processes involving activity-dependent gene expression. cAMP-response …
A neuronal pathway that controls sperm ejection and storage in female Drosophila
In polyandrous females, sperm storage permits competition between sperm of different
mates, and in some species females influence the relative fertilization success of competing …
mates, and in some species females influence the relative fertilization success of competing …
Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila
LKB1 plays important roles in governing energy homeostasis by regulating AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, including the salt-inducible kinases …
protein kinase (AMPK) and other AMPK-related kinases, including the salt-inducible kinases …
Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by …
Y Wang, L Liu, JH Gu, CN Wang, W Guan, Y Liu… - Molecular …, 2024 - nature.com
Elucidating the molecular mechanism underlying the hyperactivity of the hypothalamic–
pituitary–adrenal axis during chronic stress is critical for understanding depression and …
pituitary–adrenal axis during chronic stress is critical for understanding depression and …
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
MC Wehr, MV Holder, I Gailite, RE Saunders… - Nature cell …, 2013 - nature.com
The specification of tissue size during development involves the coordinated action of many
signalling pathways responding to organ-intrinsic signals, such as morphogen gradients …
signalling pathways responding to organ-intrinsic signals, such as morphogen gradients …