Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neu Oncogene
DJ Slamon, GM Clark, SG Wong, WJ Levin, A Ullrich… - science, 1987 - science.org
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to,
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …
Studies of the HER-2/neu Proto-Oncogene in Human Breast and Ovarian Cancer
DJ Slamon, W Godolphin, LA Jones, JA Holt, SG Wong… - Science, 1989 - science.org
Carcinoma of the breast and ovary account for one-third of all cancers occurring in women
and together are responsible for approximately one-quarter of cancer-related deaths in …
and together are responsible for approximately one-quarter of cancer-related deaths in …
Signal transduction by receptors with tyrosine kinase activity
A Ullrich, J Schlessinger - Cell, 1990 - Elsevier
The previously established classification (Yarden and Ullrich, 1988) has been extended by
recently described receptor tyrosine kinases such as HER3/c-erbB-3 (Kraus et al., 1989) IRR (…
recently described receptor tyrosine kinases such as HER3/c-erbB-3 (Kraus et al., 1989) IRR (…
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
A Ullrich, L Coussens, JS Hayflick, TJ Dull, A Gray… - Nature, 1984 - nature.com
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor
precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells…
precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells…
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
A Ullrich, JR Bell, EY Chen, R Herrera, LM Petruzzelli… - Nature, 1985 - nature.com
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor
precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid …
precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid …
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
L Coussens, TL Yang-Feng, YC Liao, E Chen, A Gray… - Science, 1985 - science.org
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
B Millauer, S Wizigmann-Voos, H Schnürch, R Martinez… - Cell, 1993 - cell.com
Examination of f/kl receptor tyrosine kinase mRNA expression by in situ hybridization analysis
revealed specific association with endothelial cells at all stages of mouse development, …
revealed specific association with endothelial cells at all stages of mouse development, …
Growth factor receptor tyrosine kinases
Y Yarden, A Ullrich - Annual review of biochemistry, 1988 - annualreviews.org
A large number of serum growth factors stimulate cellular mitogenesis by interaction with a
family of cell-surface receptors that possess an intrinsic, ligand-sensitive, protein tyrosine …
family of cell-surface receptors that possess an intrinsic, ligand-sensitive, protein tyrosine …
Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
A Ullrich, A Gray, AW Tam, T Yang‐Feng… - The EMBO …, 1986 - embopress.org
To identify structural characteristics of the closely related cell surface receptors for insulin
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
N Prenzel, E Zwick, H Daub, M Leserer, R Abraham… - Nature, 1999 - nature.com
Cross-communication between different signalling systems allows the integration of the
great diversity of stimuli that a cell receives under varying physiological situations. The …
great diversity of stimuli that a cell receives under varying physiological situations. The …