… and Lmna L530P knockin will help the study of progeria. Lmna mutations have also recently
been found in patients with atypical forms of progeria. The discovery of the HGPS mutations …

… mutations, and in non‐classical progeria, in whom growth can be … Pattern of inheritance of
non‐classical progeria is most … Of 34 LMNA mutations found in progeria patients, there were …

• Progeria, also known as the Hutchinson-Gilford syndrome, is an extremely rare condition
that was initially reported by Johnathan Hutchinson in 1886 and further described by Hastings …

Background Hutchinson–Gilford progeria syndrome is a rare, sporadic, autosomal dominant
syndrome that involves premature aging, generally leading to death at approximately 13 …

… In a transgenic mouse model of progeria with expression of the most common HGPS mutation
in brain, skin, bone, and heart, there are distortions of neuronal nuclei at the ultrastructural …

Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that offers
considerable insight into the biology of premature aging. This review summarizes the clinical …

… Children with progeria usually appear normal at birth and in early infancy. … Dr Gordon is an
investigator for progeria clinical treatment trials being conducted at Boston Children's Hospital…

… Exciting recent findings regarding a severe human progeria, Hutchinson–Gilford progeria …
of longevity, lead to a hypothesis whereby progeria syndromes accelerate a subset of the …

… Hutchinson–Gilford progeria syndrome (HGPS) and atypical Werner’s syndrome. The
phenotypes of both HGPS patients and a mouse model of progeria suggest diverse compromised …

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more
prevalent in our societies. A better understanding of how aging promotes CVD is therefore …