サンプル結果 昨年 の検索 結果 の件数 は 21 件 です。
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of
aging and disease in animal models, and growing links to human disease. This …
senescence has moved beyond the culture dish and is now a bona fide driver of
aging and disease in animal models, and growing links to human disease. This …
The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions
Lamins are inner nuclear membrane proteins that belong to the intermediate filament
family. Lamin A/C lie adjacent to the heterochromatin structure in polymer form,
providing skeletal to the nucleus. Based on the localization, lamin A/C provides …
family. Lamin A/C lie adjacent to the heterochromatin structure in polymer form,
providing skeletal to the nucleus. Based on the localization, lamin A/C provides …
Hutchinson-Gilford progeria syndrome: Cellular mechanisms and therapeutic perspectives
In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which
ultimately lead to death. The study of Hutchinson-Gilford progeria syndrome (HGPS) …
functions, with the concomitant onset of chronic-degenerative diseases, which
ultimately lead to death. The study of Hutchinson-Gilford progeria syndrome (HGPS) …
Base editing and prime editing: potential therapeutic options for rare and common diseases
Collectively, genetic disorders affect approximately 350 million individuals worldwide
and are a major global health burden. Despite substantial progress in identification
of new disease-causing genes, variants, and molecular etiologies, nearly all rare …
and are a major global health burden. Despite substantial progress in identification
of new disease-causing genes, variants, and molecular etiologies, nearly all rare …
What Causes Premature Coronary Artery Disease?
Abstract Purpose of Review This review provides an overview of genetic and non-
genetic causes of premature coronary artery disease (pCAD). Recent Findings pCAD
refers to coronary artery disease (CAD ) occurring before the age of 65 years in …
genetic causes of premature coronary artery disease (pCAD). Recent Findings pCAD
refers to coronary artery disease (
Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson–Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease that causes
premature aging symptoms, such as vascular diseases, lipodystrophy, loss of bone
mineral density, and alopecia. HGPS is mostly linked to a heterozygous and de novo …
premature aging symptoms, such as vascular diseases, lipodystrophy, loss of bone
mineral density, and alopecia. HGPS is mostly linked to a heterozygous and de novo …
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Hutchinson–Gilford progeria syndrome (HGPS) is a rare disease caused by the
expression of progerin, a mutant protein that accelerates aging and precipitates
death. Given that atherosclerosis complications are the main cause of death in …
expression of progerin, a mutant protein that accelerates aging and precipitates
death. Given that atherosclerosis complications are the main cause of death in …
Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes
Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS),
Werner syndrome (WS) and Cockayne syndrome (CS), result in severely reduced
lifespans and premature ageing. Normal senescent cells show splicing factor …
Werner syndrome (WS) and Cockayne syndrome (CS), result in severely reduced
lifespans and premature ageing. Normal senescent cells show splicing factor …
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important …
Characterizing the molecular deficiencies underlying human aging has been a
formidable challenge as it is clear that a complex myriad of factors including genetic
mutations, environmental influences, and lifestyle choices influence the deterioration …
formidable challenge as it is clear that a complex myriad of factors including genetic
mutations, environmental influences, and lifestyle choices influence the deterioration …
Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope
Background Nme2ABE8e has been constructed and characterized as a compact,
accurate adenine base editor with a less restrictive dinucleotide protospacer-
adjacent motif (PAM: N4CC) but low editing efficiency at challenging loci in human …
accurate adenine base editor with a less restrictive dinucleotide protospacer-
adjacent motif (PAM: N4CC) but low editing efficiency at challenging loci in human …