E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

This review of challenging diagnostic issues concerning high-grade endometrial carcinomas
is derived from the authors' review of the literature followed by discussions at the …

It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1αあるふぁ) is involved in cancer
metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a …

Dedifferentiated endometrial carcinoma is an aggressive type of endometrial cancer that
contains a mix of low-grade endometrioid and undifferentiated carcinoma components. We …

Abstract The Cancer Genome Atlas recently identified a genomic-based molecular
classification of endometrial carcinomas, with 4 molecular categories:(1) ultramutated …

Simple Summary Identification of mismatch repair-deficient tumors (MMRd), which occur in
up to 30% of all endometrial cancers (EC), has become unavoidable for therapeutic …

The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2
peptide hormones, their corresponding receptors and several IGF binding proteins, is …

Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly
aggressive subtypes of uterine cancer, not well characterized at a molecular level. To …

Immune responses against thyroid carcinomas have long been demonstrated and
associations between inflammatory microenvironment and thyroid carcinomas repeatedly …

Undifferentiated carcinoma of the endometrium (UCAe) is an aggressive, underrecognized
high-grade carcinoma that can occur either in pure form or in conjunction with low-grade …