Simple Summary Childhood cancers are mostly of unknown etiology and represent
devastating diagnoses. The clinical benefits of steadily increasing tumor control and survival …

Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

PURPOSE Ewing 2008R3 was conducted in 12 countries and evaluated the effect of
treosulfan and melphalan high-dose chemotherapy (TreoMel-HDT) followed by reinfusion of …

Simple Summary Even today, a malignant bone tumor is still a threatening condition for the
patient. Such tumors are difficult to treat and they require an interdisciplinary approach to …

The ever-changing nature of cancer poses the most difficult challenge oncologists face
today. Cancer's remarkable adaptability has inspired many to work toward understanding …

Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …

The expression pattern, diagnostic value, and association of PD-L1, IFN-γがんま and TGF-βべーた with
bone tumor type, severity, and relapse are determined in this study. 300 human samples …

Purpose: Histone deacetylase (HDAC) inhibition has been shown to induce pharmacologic
“BRCAness” in cancer cells with proficient DNA repair activity. This provides a rationale for …

Abstract Purpose: Ewing sarcoma (EwS) is a highly malignant pediatric tumor characterized
by a non-T-cell-inflamed immune-evasive phenotype. When relapsed or metastasized …

Fli-1, a member of the ETS family of transcription factors, was discovered in 1991 through
retroviral insertional mutagenesis as a driver of mouse erythroleukemias. In the past 30 …