The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice
Abstract
Infections caused by the bacteria Chlamydia trachomatis contribute to diverse pathologies in a variety of human populations. We previously used a systemic model of C. trachomatis infection in mice to map three quantitative trait loci that influence in vivo susceptibility differences between the C57BL/6J and C3H/HeJ inbred strains of mouse. One of these quantitative trait loci, Ctrq-3, influences an IFN-
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- September 2006
- DOI:
- 10.1073/pnas.0603338103
- Bibcode:
- 2006PNAS..10314092B
- Keywords:
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- BIOLOGICAL SCIENCES / IMMUNOLOGY