Sci. Aging Knowl. Environ., Vol. 2006, Issue 10, pp. dn1, 28 June 2006
[DOI: 10.1126/sageke.2006.10.dn1]

Dementia with Cerebrovascular Disease

Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell and Lawrence S. Honig
The authors are at Columbia University College of Physicians and Surgeons, in the Departments of Neurology (C.B.W., K.B., L.S.H.) and Pathology (J.P.G.V.), and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (K.B., J.P.G.V., L.S.H.) and the Gertrude H. Sergievsky Center (K.B., L.S.H.), New York, NY 10032, USA. E-mail: CWright{at}neuro.columbia.edu (C.B.W.); lh456{at}columbia.edu (L.S.H.)

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Document URL: http://sageke.sciencemag.org/cgi/content/full/2006/10/dn1

Key words: Alzheimer's disease • cerebrovascular disease • stroke • dementia • subcortical arteriosclerotic encephalopathy

In this case study, we review the symptoms, cognitive testing, brain imaging, and brain pathology of a woman with dementia, for whom the neuropathological findings suggest a prominent contribution of cerebrovascular disease. Vascular dementia is the term commonly used for persons with dementia resulting from strokes, either clinically evident or subclinical "silent" events. "Mixed dementia" is the term used when there is an admixture of pathological findings related to Alzheimer's disease (AD) and cerebrovascular disease, as in this situation. In some cases of mixed dementia, the pathological involvement of AD may be the principal contributory cause of the cognitive symptoms, and in others, the vascular changes may give the greater contribution.

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Citation: C. B. Wright, J. P. G. Vonsattel, K. Bell, L. S. Honig, Dementia with Cerebrovascular Disease. Sci. Aging Knowl. Environ. 2006 (10), dn1 (2006).